1s1j

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(New page: 200px<br /><applet load="1s1j" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s1j, resolution 2.18&Aring;" /> '''Crystal Structure of...)
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[[Image:1s1j.jpg|left|200px]]<br /><applet load="1s1j" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1s1j, resolution 2.18&Aring;" />
 
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'''Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1'''<br />
 
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==Overview==
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==Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1==
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The binding of FtsZ to ZipA is a potential target for antibacterial, therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key, region of ZipA involved in FtsZ binding. The X-ray crystal structure of, one of these molecules complexed with ZipA was solved. The structure, revealed an unexpected binding mode, facilitated by desolvation of a, loosely bound surface water.
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<StructureSection load='1s1j' size='340' side='right'caption='[[1s1j]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S1J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IQZ:(12BS)-1,2,3,4,12,12B-HEXAHYDROINDOLO[2,3-A]QUINOLIZIN-7(6H)-ONE'>IQZ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1j OCA], [https://pdbe.org/1s1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s1j RCSB], [https://www.ebi.ac.uk/pdbsum/1s1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ZIPA_ECOLI ZIPA_ECOLI] Interacts directly with the cell division protein FtsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane.[HAMAP-Rule:MF_00509]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s1j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s1j ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1S1J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with IQZ as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1S1J OCA].
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*[[Cell division protein 3D structures|Cell division protein 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction., Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15006376 15006376]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ding, W.]]
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[[Category: Ding W]]
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[[Category: Dushin, E.G.]]
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[[Category: Dushin EG]]
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[[Category: Foreman, K.W.]]
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[[Category: Foreman KW]]
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[[Category: III, T.S.Rush.]]
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[[Category: Jenning LD]]
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[[Category: Jenning, L.D.]]
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[[Category: Kenney CH]]
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[[Category: Kenney, C.H.]]
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[[Category: Li Y]]
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[[Category: Li, Y.]]
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[[Category: Moghazeh SL]]
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[[Category: Moghazeh, S.L.]]
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[[Category: Mosyak L]]
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[[Category: Mosyak, L.]]
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[[Category: Peterson PJ]]
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[[Category: Peterson, P.J.]]
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[[Category: Rush III TS]]
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[[Category: Ruzin, A.V.]]
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[[Category: Ruzin AV]]
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[[Category: Sukhdeo, M.N.]]
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[[Category: Sukhdeo MN]]
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[[Category: Sutherland, A.G.]]
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[[Category: Sutherland AG]]
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[[Category: Tsao, D.H.]]
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[[Category: Tsao DH]]
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[[Category: Tuckman, M.]]
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[[Category: Tuckman M]]
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[[Category: IQZ]]
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[[Category: cell cycle]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:02:19 2007''
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Current revision

Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1

PDB ID 1s1j

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