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1s7o

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[[Image:1s7o.gif|left|200px]]<br /><applet load="1s7o" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1s7o, resolution 2.31&Aring;" />
 
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'''Crystal structure of putative DNA binding protein SP_1288 from Streptococcus pygenes'''<br />
 
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==Overview==
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==Crystal structure of putative DNA binding protein SP_1288 from Streptococcus pygenes==
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The crystal structure of the putative DNA-binding protein SP_1288 (gi/15675166, also listed as gi/28895954) from Streptococcus pyogenes has been determined by X-ray crystallography to a resolution of 2.3 A using anomalous diffraction data at the Se peak wavelength. SP_1288 belongs to a family of proteins whose cellular function is associated with the signal recognition particle; no structural information has been available until now about the members of the family. Crystallographic analysis revealed that the overall fold of SP_1288 consists exclusively of alpha-helices and that 75% of the structure has good similarity to domain 4 of the sigma subunit of RNA polymerase. This suggests its possible involvement in the biochemical function of transcription initiation, which includes interaction with DNA.
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<StructureSection load='1s7o' size='340' side='right'caption='[[1s7o]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1s7o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M3 Streptococcus pyogenes serotype M3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S7O FirstGlance]. <br>
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1S7O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7O OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7o OCA], [https://pdbe.org/1s7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s7o RCSB], [https://www.ebi.ac.uk/pdbsum/1s7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s7o ProSAT], [https://www.topsan.org/Proteins/BSGC/1s7o TOPSAN]</span></td></tr>
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==Reference==
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</table>
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Structure of the putative DNA-binding protein SP_1288 from Streptococcus pyogenes., Oganesyan V, Pufan R, DeGiovanni A, Yokota H, Kim R, Kim SH, Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1266-71. Epub 2004, Jun 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15213388 15213388]
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== Function ==
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[[Category: Single protein]]
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[https://www.uniprot.org/uniprot/Y842_STRP3 Y842_STRP3] Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein (By similarity).
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[[Category: Streptococcus pyogenes]]
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== Evolutionary Conservation ==
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[[Category: BSGC, Berkeley Structural Genomics Center.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: DeGiovanni, A.]]
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Check<jmol>
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[[Category: Kim, R.]]
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<jmolCheckbox>
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[[Category: Kim, S H.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s7/1s7o_consurf.spt"</scriptWhenChecked>
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[[Category: Oganesyan, V.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Pufan, R.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Yokota, H.]]
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</jmolCheckbox>
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[[Category: berkeley structural genomics center]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s7o ConSurf].
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[[Category: bsgc]]
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<div style="clear:both"></div>
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[[Category: protein structure initiative]]
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__TOC__
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[[Category: psi]]
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</StructureSection>
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[[Category: putative dna binding protein; structural genomics]]
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[[Category: Large Structures]]
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[[Category: rna polymerase sigma factor]]
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[[Category: Streptococcus pyogenes serotype M3]]
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[[Category: signal recognition particle]]
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[[Category: DeGiovanni A]]
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[[Category: structure funded by nih]]
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[[Category: Kim R]]
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[[Category: upf0122]]
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[[Category: Kim S-H]]
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[[Category: x-rat crystallography]]
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[[Category: Oganesyan V]]
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[[Category: Pufan R]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:58:49 2008''
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[[Category: Yokota H]]

Current revision

Crystal structure of putative DNA binding protein SP_1288 from Streptococcus pygenes

PDB ID 1s7o

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