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1s9k

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Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site

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Categories: Homo sapiens | Large Structures | Chen L | Stroud JC | Wang D

@@ Line 3: / Line 3: @@
 <StructureSection load='1s9k' size='340' side='right'caption='[[1s9k]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1s9k]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1S9K FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1s9k]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S9K FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a02|1a02]], [[1imh|1imh]], [[1a66|1a66]], [[1fos|1fos]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NFATC2, NFAT1, NFATP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), FOS, G0S7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), JUN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s9k OCA], [https://pdbe.org/1s9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s9k RCSB], [https://www.ebi.ac.uk/pdbsum/1s9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s9k ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1s9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s9k OCA], [http://pdbe.org/1s9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s9k RCSB], [http://www.ebi.ac.uk/pdbsum/1s9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s9k ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/FOS_HUMAN FOS_HUMAN]] Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.<ref>PMID:7588633</ref> <ref>PMID:9732876</ref> <ref>PMID:16055710</ref>  [[http://www.uniprot.org/uniprot/NFAC2_HUMAN NFAC2_HUMAN]] Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.<ref>PMID:21871017</ref>  [[http://www.uniprot.org/uniprot/JUN_HUMAN JUN_HUMAN]] Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.<ref>PMID:10995748</ref> <ref>PMID:17210646</ref>
+[https://www.uniprot.org/uniprot/NFAC2_HUMAN NFAC2_HUMAN] Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.<ref>PMID:21871017</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 24: / Line 23: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Chen, L]]
+[[Category: Chen L]]
-[[Category: Stroud, J C]]
+[[Category: Stroud JC]]
-[[Category: Wang, D]]
+[[Category: Wang D]]
-[[Category: B-zip]]
-[[Category: Basic leucine zipper]]
-[[Category: Beta barrel]]
-[[Category: Coiled coil]]
-[[Category: Complex]]
-[[Category: Double helix]]
-[[Category: Protein-dna complex]]
-[[Category: Ternary]]
-[[Category: Transcription-dna complex]]

1s9k

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Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site

Structural highlights

Function

Evolutionary Conservation

References

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