1sei

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(New page: 200px<br /><applet load="1sei" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sei, resolution 1.9&Aring;" /> '''STRUCTURE OF 30S RIBO...)
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[[Image:1sei.jpg|left|200px]]<br /><applet load="1sei" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1sei, resolution 1.9&Aring;" />
 
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'''STRUCTURE OF 30S RIBOSOMAL PROTEIN S8'''<br />
 
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==Overview==
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==STRUCTURE OF 30S RIBOSOMAL PROTEIN S8==
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BACKGROUND. Prokaryotic ribosomal protein S8 is an important RNA-binding, protein that occupies a central position within the small ribosomal, subunit. It interacts extensively with 16S rRNA and is crucial for the, correct folding of the central domain of the rRNA. S8 also controls the, synthesis of several ribosomal proteins by binding to mRNA. It binds, specifically to very similar sites in the two RNA molecules. RESULTS. S8, is divided into two tightly associated domains and contains three regions, that are proposed to interact with other ribosomal components: two, potential RNA-binding sites, and a hydrophobic patch that may interact, with a complementary hydrophobic region of S5. The N-terminal domain fold, is found in several proteins including two that bind double-stranded DNA., CONCLUSIONS. These multiple RNA-binding sites are consistent with the role, of S8 in organizing the central domain and agree with the latest models of, the 16S RNA which show that the S8 location coincides with a region of, complicated nucleic-acid structure. The presence in a wide variety of, proteins of a region homologous to the N-terminal domain supports the idea, that ribosomal proteins must represent some of the earliest protein, molecules.
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<StructureSection load='1sei' size='340' side='right'caption='[[1sei]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sei]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SEI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SEI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sei OCA], [https://pdbe.org/1sei PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sei RCSB], [https://www.ebi.ac.uk/pdbsum/1sei PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sei ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RS8_GEOSE RS8_GEOSE] One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.[HAMAP-Rule:MF_01302]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/se/1sei_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sei ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1SEI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SEI OCA].
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*[[Ribosomal protein S8|Ribosomal protein S8]]
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__TOC__
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==Reference==
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</StructureSection>
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Structural evidence for specific S8-RNA and S8-protein interactions within the 30S ribosomal subunit: ribosomal protein S8 from Bacillus stearothermophilus at 1.9 A resolution., Davies C, Ramakrishnan V, White SW, Structure. 1996 Sep 15;4(9):1093-104. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8805594 8805594]
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[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Davies, C.]]
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[[Category: Davies C]]
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[[Category: Ramakrishnan, V.]]
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[[Category: Ramakrishnan V]]
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[[Category: White, S.W.]]
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[[Category: White SW]]
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[[Category: prokaryotic]]
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[[Category: ribosomal protein]]
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[[Category: rrna-binding]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:19:12 2007''
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Current revision

STRUCTURE OF 30S RIBOSOMAL PROTEIN S8

PDB ID 1sei

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