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1sj4

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[[Image:1sj4.png|left|200px]]
 
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{{STRUCTURE_1sj4| PDB=1sj4 | SCENE= }}
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==Crystal structure of a C75U mutant Hepatitis Delta Virus ribozyme precursor, in Cu2+ solution==
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<StructureSection load='1sj4' size='340' side='right'caption='[[1sj4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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===Crystal structure of a C75U mutant Hepatitis Delta Virus ribozyme precursor, in Cu2+ solution===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sj4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_delta_virus Hepatitis delta virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SJ4 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15141216}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sj4 OCA], [https://pdbe.org/1sj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sj4 RCSB], [https://www.ebi.ac.uk/pdbsum/1sj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sj4 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1sj4]] is a 2 chain structure of [[Nucleoprotein]] and [[Ribozyme]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_delta_virus Hepatitis delta virus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ4 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sj/1sj4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sj4 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nucleoprotein|Nucleoprotein]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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*[[Ribozyme|Ribozyme]]
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*[[Ribozyme 3D structures|Ribozyme 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015141216</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Hepatitis delta virus]]
[[Category: Hepatitis delta virus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cate, J H.]]
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[[Category: Large Structures]]
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[[Category: Ding, F.]]
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[[Category: Cate JH]]
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[[Category: Doudna, J A.]]
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[[Category: Ding F]]
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[[Category: Ke, A.]]
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[[Category: Doudna JA]]
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[[Category: Zhou, K.]]
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[[Category: Ke A]]
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[[Category: Hdv]]
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[[Category: Zhou K]]
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[[Category: Precurosr]]
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[[Category: Ribozyme]]
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[[Category: Rna]]
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[[Category: Translation-rna complex]]
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[[Category: U1a]]
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Current revision

Crystal structure of a C75U mutant Hepatitis Delta Virus ribozyme precursor, in Cu2+ solution

PDB ID 1sj4

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