1sjs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="1sjs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sjs, resolution 2.42&Aring;" /> '''ACCESS TO PHOSPHORY...)
Current revision (08:31, 14 February 2024) (edit) (undo)
 
(23 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1sjs.gif|left|200px]]<br />
 
-
<applet load="1sjs" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1sjs, resolution 2.42&Aring;" />
 
-
'''ACCESS TO PHOSPHORYLATION IN ISOCITRATE DEHYDROGENASE MAY OCCUR BY DOMAIN SHIFTING'''<br />
 
-
==Overview==
+
==ACCESS TO PHOSPHORYLATION IN ISOCITRATE DEHYDROGENASE MAY OCCUR BY DOMAIN SHIFTING==
-
To clarify further the mechanism of regulation by phosphorylation of, isocitrate dehydrogenase, cocrystallization of isocitrate dehydrogenase, and isocitrate dehydrogenase kinase/phosphatase in the presence of an ATP, analog was attempted. Although cocrystallization was unsuccessful, a new, crystal form of isocitrate dehydrogenase was obtained which provides, insight into the phosphorylation mechanism. The new, orthorhombic crystal, form of isocitrate dehydrogenase is related to the previously reported, tetragonal form largely by an approximately 16 degrees shift of a large, domain relative to the small domain and clasp region within each subunit, of the dimeric enzyme. The NADP+ cofactor binding surface is significantly, disrupted by the shift to the open conformation. The ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9374867 (full description)]]
+
<StructureSection load='1sjs' size='340' side='right'caption='[[1sjs]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1sjs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SJS FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sjs OCA], [https://pdbe.org/1sjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sjs RCSB], [https://www.ebi.ac.uk/pdbsum/1sjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sjs ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IDH_ECOLI IDH_ECOLI]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sj/1sjs_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sjs ConSurf].
 +
<div style="clear:both"></div>
-
==About this Structure==
+
==See Also==
-
1SJS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SJS OCA]].
+
*[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]]
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting., Finer-Moore J, Tsutakawa SE, Cherbavaz DR, LaPorte DC, Koshland DE Jr, Stroud RM, Biochemistry. 1997 Nov 11;36(45):13890-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9374867 9374867]
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Finer-Moore, J.]]
+
[[Category: Finer-Moore J]]
-
[[Category: Stroud, R.M.]]
+
[[Category: Stroud RM]]
-
[[Category: i oxidoreductase]]
+
-
[[Category: nad(a) - choh(d)]]
+
-
[[Category: phosphorylation]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:36:33 2007''
+

Current revision

ACCESS TO PHOSPHORYLATION IN ISOCITRATE DEHYDROGENASE MAY OCCUR BY DOMAIN SHIFTING

PDB ID 1sjs

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1sjs"
Personal tools