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1sqw

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[[Image:1sqw.gif|left|200px]]
 
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{{Structure
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==Crystal structure of KD93, a novel protein expressed in the human pro==
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|PDB= 1sqw |SIZE=350|CAPTION= <scene name='initialview01'>1sqw</scene>, resolution 1.9&Aring;
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<StructureSection load='1sqw' size='340' side='right'caption='[[1sqw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1sqw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQW FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE= novel gene ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqw OCA], [https://pdbe.org/1sqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sqw RCSB], [https://www.ebi.ac.uk/pdbsum/1sqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sqw ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''Crystal structure of KD93, a novel protein expressed in the human pro'''
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[https://www.uniprot.org/uniprot/NIP7_HUMAN NIP7_HUMAN] Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.<ref>PMID:22195017</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The crystal structure of a novel hypothetical protein, KD93, expressed in human hematopoietic stem/progenitor cells, was determined at 1.9A resolution using the multiple-wavelength anomalous dispersion (MAD) method. The protein KD93, which is encoded by the open reading frame HSPC031, is a NIP7 homologue and belongs to the UPF0113 family. The structural and functional information for the group of homologues has not yet been determined. Crystallographic analysis revealed that the overall fold of KD93 consists of two interlinked alpha/beta domains. Structure-based homology analysis with DALI revealed that the C domain of KD93 matches the PUA domain of some RNA modification enzymes, especially that of archaeosine tRNA-ribosyltransferase (ArcTGT), which suggests that its possible molecular function is related to RNA binding. The difference between the RNA binding regions of KD93 and ArcTGT in amino acid constitution and surface electrostatic potential indicate that they may have different RNA binding modes. The N domain of KD93 is a unique structure with no obvious similarity to other proteins with known three-dimensional structures. The high-resolution structure of KD93 provides a first view of a member of the family of hypothetical proteins. And the structure provides a framework to deduce and assay the molecular function of other proteins of the UPF0113 family.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sqw_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1SQW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQW OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sqw ConSurf].
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Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells., Liu JF, Wang XQ, Wang ZX, Chen JR, Jiang T, An XM, Chang WR, Liang DC, J Struct Biol. 2004 Dec;148(3):370-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15522784 15522784]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: An, X M.]]
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[[Category: An XM]]
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[[Category: Chan, W R.]]
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[[Category: Chan WR]]
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[[Category: Chen, J R.]]
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[[Category: Chen JR]]
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[[Category: Jiang, T.]]
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[[Category: Jiang T]]
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[[Category: Liang, D C.]]
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[[Category: Liang DC]]
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[[Category: Liu, J F.]]
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[[Category: Liu JF]]
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[[Category: Wang, X Q.]]
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[[Category: Wang XQ]]
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[[Category: Wang, Z X.]]
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[[Category: Wang ZX]]
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[[Category: pua]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:08:32 2008''
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Current revision

Crystal structure of KD93, a novel protein expressed in the human pro

PDB ID 1sqw

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