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1t6m

From Proteopedia

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{{Seed}}
 
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[[Image:1t6m.png|left|200px]]
 
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==X-ray Structure of the R70D PI-PLC enzyme: Insight into the role of calcium and surrounding amino acids on active site geometry and catalysis.==
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The line below this paragraph, containing "STRUCTURE_1t6m", creates the "Structure Box" on the page.
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<StructureSection load='1t6m' size='340' side='right'caption='[[1t6m]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t6m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T6M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.107&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1t6m| PDB=1t6m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6m OCA], [https://pdbe.org/1t6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t6m RCSB], [https://www.ebi.ac.uk/pdbsum/1t6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t6m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLC_BACTU PLC_BACTU] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t6m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t6m ConSurf].
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<div style="clear:both"></div>
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===X-ray Structure of the R70D PI-PLC enzyme: Insight into the role of calcium and surrounding amino acids on active site geometry and catalysis.===
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==See Also==
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*[[Phospholipase C|Phospholipase C]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16042375}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16042375 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16042375}}
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==About this Structure==
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1T6M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6M OCA].
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==Reference==
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X-ray structure of the R69D phosphatidylinositol-specific phospholipase C enzyme: insight into the role of calcium and surrounding amino acids in active site geometry and catalysis., Apiyo D, Zhao L, Tsai MD, Selby TL, Biochemistry. 2005 Aug 2;44(30):9980-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16042375 16042375]
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[[Category: Bacillus thuringiensis]]
[[Category: Bacillus thuringiensis]]
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[[Category: Phosphatidylinositol diacylglycerol-lyase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Apiyo D]]
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[[Category: Apiyo, D.]]
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[[Category: Selby TL]]
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[[Category: Selby, T L.]]
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[[Category: Tsai M-D]]
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[[Category: Tsai, M D.]]
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[[Category: Zhao L]]
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[[Category: Zhao, L.]]
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[[Category: Pi-plc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:49:05 2008''
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Current revision

X-ray Structure of the R70D PI-PLC enzyme: Insight into the role of calcium and surrounding amino acids on active site geometry and catalysis.

PDB ID 1t6m

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