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1t6s

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[[Image:1t6s.jpg|left|200px]]
 
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==Crystal structure of a conserved hypothetical protein from Chlorobium tepidum==
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The line below this paragraph, containing "STRUCTURE_1t6s", creates the "Structure Box" on the page.
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<StructureSection load='1t6s' size='340' side='right'caption='[[1t6s]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t6s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlorobaculum_tepidum_TLS Chlorobaculum tepidum TLS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T6S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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{{STRUCTURE_1t6s| PDB=1t6s | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6s OCA], [https://pdbe.org/1t6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t6s RCSB], [https://www.ebi.ac.uk/pdbsum/1t6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t6s ProSAT], [https://www.topsan.org/Proteins/BSGC/1t6s TOPSAN]</span></td></tr>
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</table>
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'''Crystal structure of a conserved hypothetical protein from Chlorobium tepidum'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q8KF54_CHLTE Q8KF54_CHLTE] Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity).
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Structural maintenance of chromosome (SMC) proteins are essential in chromosome condensation and interact with non-SMC proteins in eukaryotes and with segregation and condensation proteins (ScpA and ScpB) in prokaryotes. The highly conserved gene in Chlorobium tepidum gi 21646405 encodes ScpB (ScpB_ChTe). The high resolution crystal structure of ScpB_ChTe shows that the monomeric structure consists of two similarly shaped globular domains composed of three helices sided by beta-strands [a winged helix-turn-helix (HTH)], a motif observed in the C-terminal domain of Scc1, a functionally related eukaryotic ScpA homolog, as well as in many DNA binding proteins.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t6s_consurf.spt"</scriptWhenChecked>
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1T6S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Chlorobium_tepidum_tls Chlorobium tepidum tls]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6S OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of ScpB from Chlorobium tepidum, a protein involved in chromosome partitioning., Kim JS, Shin DH, Pufan R, Huang C, Yokota H, Kim R, Kim SH, Proteins. 2006 Feb 1;62(2):322-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16294331 16294331]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t6s ConSurf].
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[[Category: Chlorobium tepidum tls]]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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[[Category: BSGC, Berkeley Structural Genomics Center.]]
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</StructureSection>
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[[Category: Kim, J S.]]
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[[Category: Chlorobaculum tepidum TLS]]
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[[Category: Kim, R.]]
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[[Category: Large Structures]]
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[[Category: Kim, S H.]]
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[[Category: Kim JS]]
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[[Category: Shin, D H.]]
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[[Category: Kim R]]
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[[Category: A winged helix-turn-helix]]
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[[Category: Kim SH]]
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[[Category: Berkeley structural genomics center]]
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[[Category: Shin DH]]
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[[Category: Bsgc structure funded by nih]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:36:06 2008''
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Current revision

Crystal structure of a conserved hypothetical protein from Chlorobium tepidum

PDB ID 1t6s

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