1t94

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[[Image:1t94.png|left|200px]]
 
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{{STRUCTURE_1t94| PDB=1t94 | SCENE= }}
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==Crystal structure of the catalytic core of human DNA polymerase kappa==
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<StructureSection load='1t94' size='340' side='right'caption='[[1t94]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Crystal structure of the catalytic core of human DNA polymerase kappa===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1t94]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T94 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15296733}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t94 OCA], [https://pdbe.org/1t94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t94 RCSB], [https://www.ebi.ac.uk/pdbsum/1t94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t94 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1t94]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T94 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/POLK_HUMAN POLK_HUMAN] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.<ref>PMID:10620008</ref> <ref>PMID:11024016</ref> <ref>PMID:12145297</ref> <ref>PMID:12444249</ref> <ref>PMID:12952891</ref> <ref>PMID:14630940</ref> <ref>PMID:15533436</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t9/1t94_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t94 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA polymerase|DNA polymerase]]
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015296733</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Aggarwal, A K.]]
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[[Category: Large Structures]]
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[[Category: Edwards, T A.]]
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[[Category: Aggarwal AK]]
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[[Category: Johnson, R E.]]
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[[Category: Edwards TA]]
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[[Category: Prakash, L.]]
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[[Category: Johnson RE]]
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[[Category: Prakash, S.]]
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[[Category: Prakash L]]
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[[Category: Uljon, S N.]]
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[[Category: Prakash S]]
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[[Category: Dna repair]]
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[[Category: Uljon SN]]
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[[Category: Lesion bypass]]
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[[Category: Replication]]
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[[Category: Translesion dna synthesis]]
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[[Category: Y-family dna polymerase]]
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Current revision

Crystal structure of the catalytic core of human DNA polymerase kappa

PDB ID 1t94

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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