1t9h
From Proteopedia
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| - | [[Image:1t9h.png|left|200px]] | ||
| - | + | ==The crystal structure of YloQ, a circularly permuted GTPase.== | |
| - | + | <StructureSection load='1t9h' size='340' side='right'caption='[[1t9h]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1t9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T9H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IUM:URANYL+(VI)+ION'>IUM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t9h OCA], [https://pdbe.org/1t9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t9h RCSB], [https://www.ebi.ac.uk/pdbsum/1t9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t9h ProSAT]</span></td></tr> |
| - | [[1t9h]] is a 1 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/RSGA_BACSU RSGA_BACSU] Depletion of yloQ results in sensitization towards protein synthesis inhibitors that block the peptide channel or peptidyl transferase center on the ribosome, implying that YloQ functions in conjunction with the ribosome in vivo. Decreasing levels of YloQ lead to an increase in unassembled 30S and 50S subunit and a decrease in the assembled 70S ribosome. May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity). Dispensible for viability, but important for overall fitness. |
| - | < | + | == Evolutionary Conservation == |
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t9/1t9h_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t9h ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
| - | [[Category: Antson | + | [[Category: Large Structures]] |
| - | [[Category: Blagova | + | [[Category: Antson AA]] |
| - | [[Category: Brannigan | + | [[Category: Blagova EV]] |
| - | [[Category: Cladiere | + | [[Category: Brannigan JA]] |
| - | [[Category: Isupov | + | [[Category: Cladiere L]] |
| - | [[Category: Levdikov | + | [[Category: Isupov MN]] |
| - | [[Category: Seror | + | [[Category: Levdikov VM]] |
| - | [[Category: Wilkinson | + | [[Category: Seror SJ]] |
| - | + | [[Category: Wilkinson AJ]] | |
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Current revision
The crystal structure of YloQ, a circularly permuted GTPase.
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