This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1taf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1taf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1taf, resolution 2.0&Aring;" /> '''DROSOPHILA TBP ASSOCI...)
Current revision (08:38, 14 February 2024) (edit) (undo)
 
(15 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1taf.gif|left|200px]]<br /><applet load="1taf" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1taf, resolution 2.0&Aring;" />
 
-
'''DROSOPHILA TBP ASSOCIATED FACTORS DTAFII42/DTAFII62 HETEROTETRAMER'''<br />
 
-
==Overview==
+
==DROSOPHILA TBP ASSOCIATED FACTORS DTAFII42/DTAFII62 HETEROTETRAMER==
-
A complex of two TFIID TATA box-binding protein-associated factors (TA, FIIs) is described at 2.0A resolution. The amino-terminal portions of, dTAFII42 and dTAFII62 from Drosophila adopt the canonical histone fold, consisting of two short alpha-helices flanking a long central alpha-helix., Like histones H3 and H4, dTAFII42 and dTAFII62 form an intimate, heterodimer by extensive hydrophobic contacts between the paired, molecules. In solution and in the crystalline state, the dTAFII42/dTAFII62, complex exists as a heterotetramer, resembling the (H3/H4)2, heterotetrameric core of the histone octamer, suggesting that TFIID, contains a histone octamer-like substructure.
+
<StructureSection load='1taf' size='340' side='right'caption='[[1taf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1taf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TAF FirstGlance]. <br>
-
1TAF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TAF OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1taf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1taf OCA], [https://pdbe.org/1taf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1taf RCSB], [https://www.ebi.ac.uk/pdbsum/1taf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1taf ProSAT]</span></td></tr>
-
Structural similarity between TAFs and the heterotetrameric core of the histone octamer., Xie X, Kokubo T, Cohen SL, Mirza UA, Hoffmann A, Chait BT, Roeder RG, Nakatani Y, Burley SK, Nature. 1996 Mar 28;380(6572):316-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8598927 8598927]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TAF9_DROME TAF9_DROME] TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.<ref>PMID:8221891</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ta/1taf_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1taf ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
-
[[Category: Protein complex]]
+
[[Category: Large Structures]]
-
[[Category: Burley, S.K.]]
+
[[Category: Burley SK]]
-
[[Category: Chait, B.T.]]
+
[[Category: Chait BT]]
-
[[Category: Cohen, S.L.]]
+
[[Category: Cohen SL]]
-
[[Category: Hoffmann, A.]]
+
[[Category: Hoffmann A]]
-
[[Category: Kokubo, T.]]
+
[[Category: Kokubo T]]
-
[[Category: Mirza, U.A.]]
+
[[Category: Mirza UA]]
-
[[Category: Nakatani, Y.]]
+
[[Category: Nakatani Y]]
-
[[Category: Roeder, R.G.]]
+
[[Category: Roeder RG]]
-
[[Category: Xie, X.]]
+
[[Category: Xie X]]
-
[[Category: ZN]]
+
-
[[Category: complex (two transcription factors)]]
+
-
[[Category: histone fold]]
+
-
[[Category: transcription initiation]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:07:01 2007''
+

Current revision

DROSOPHILA TBP ASSOCIATED FACTORS DTAFII42/DTAFII62 HETEROTETRAMER

PDB ID 1taf

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1taf"
Personal tools