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1tb5

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[[Image:1tb5.png|left|200px]]
 
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{{STRUCTURE_1tb5| PDB=1tb5 | SCENE= }}
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==Catalytic Domain Of Human Phosphodiesterase 4B In Complex With AMP==
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<StructureSection load='1tb5' size='340' side='right'caption='[[1tb5]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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===Catalytic Domain Of Human Phosphodiesterase 4B In Complex With AMP===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tb5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TB5 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15260978}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tb5 OCA], [https://pdbe.org/1tb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tb5 RCSB], [https://www.ebi.ac.uk/pdbsum/1tb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tb5 ProSAT]</span></td></tr>
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[[1tb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TB5 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/1tb5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tb5 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015260978</ref><references group="xtra"/>
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__TOC__
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Artis, D R.]]
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[[Category: Large Structures]]
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[[Category: Bollag, G.]]
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[[Category: Artis DR]]
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[[Category: Card, G L.]]
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[[Category: Bollag G]]
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[[Category: Fong, D.]]
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[[Category: Card GL]]
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[[Category: Gillette, S.]]
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[[Category: Fong D]]
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[[Category: Hsieh, D.]]
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[[Category: Gillette S]]
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[[Category: Kim, S H.]]
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[[Category: Hsieh D]]
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[[Category: Milburn, M V.]]
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[[Category: Kim S-H]]
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[[Category: Neiman, J.]]
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[[Category: Milburn MV]]
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[[Category: Schlessinger, J.]]
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[[Category: Neiman J]]
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[[Category: Suzuki, Y.]]
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[[Category: Schlessinger J]]
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[[Category: West, B L.]]
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[[Category: Suzuki Y]]
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[[Category: Zhang, C.]]
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[[Category: West BL]]
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[[Category: Zhang, K Y.J.]]
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[[Category: Zhang C]]
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[[Category: Hydrolase]]
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[[Category: Zhang KYJ]]
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[[Category: Pde4b]]
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Current revision

Catalytic Domain Of Human Phosphodiesterase 4B In Complex With AMP

PDB ID 1tb5

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