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1tbg

From Proteopedia

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{{Seed}}
 
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[[Image:1tbg.png|left|200px]]
 
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==BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN==
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The line below this paragraph, containing "STRUCTURE_1tbg", creates the "Structure Box" on the page.
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<StructureSection load='1tbg' size='340' side='right'caption='[[1tbg]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tbg]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The October 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''G Proteins'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_10 10.2210/rcsb_pdb/mom_2004_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbg OCA], [https://pdbe.org/1tbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tbg RCSB], [https://www.ebi.ac.uk/pdbsum/1tbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbg ProSAT]</span></td></tr>
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{{STRUCTURE_1tbg| PDB=1tbg | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/1tbg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tbg ConSurf].
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<div style="clear:both"></div>
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===BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN===
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==See Also==
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*[[Transducin 3D structures|Transducin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8552196}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8552196 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8552196}}
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==About this Structure==
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1TBG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Additional information on 1TBG is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb58_1.html G Proteins] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBG OCA].
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==Reference==
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Crystal structure of a G-protein beta gamma dimer at 2.1A resolution., Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB, Nature. 1996 Jan 25;379(6563):369-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8552196 8552196]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: G Proteins]]
[[Category: G Proteins]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Bohm, A.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Hamm, H E.]]
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[[Category: Bohm A]]
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[[Category: Lambright, D G.]]
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[[Category: Hamm HE]]
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[[Category: Sigler, P B.]]
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[[Category: Lambright DG]]
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[[Category: Sondek, J S.]]
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[[Category: Sigler PB]]
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[[Category: Eye]]
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[[Category: Sondek JS]]
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[[Category: Prenylation]]
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[[Category: Transducer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 11:01:25 2008''
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Current revision

BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN

PDB ID 1tbg

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