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1tdh

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[[Image:1tdh.png|left|200px]]
 
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{{STRUCTURE_1tdh| PDB=1tdh | SCENE= }}
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==Crystal structure of human endonuclease VIII-like 1 (NEIL1)==
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<StructureSection load='1tdh' size='340' side='right'caption='[[1tdh]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal structure of human endonuclease VIII-like 1 (NEIL1)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tdh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TDH FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15232006}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tdh OCA], [https://pdbe.org/1tdh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tdh RCSB], [https://www.ebi.ac.uk/pdbsum/1tdh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tdh ProSAT]</span></td></tr>
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[[1tdh]] is a 1 chain structure of [[DNA glycosylate]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TDH OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEIL1_HUMAN NEIL1_HUMAN] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.<ref>PMID:12200441</ref> <ref>PMID:12509226</ref> <ref>PMID:11904416</ref> <ref>PMID:14522990</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/td/1tdh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tdh ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[DNA glycosylate|DNA glycosylate]]
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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*[[DNA repair protein human endonuclease VIII-like 1 (NEIL1)|DNA repair protein human endonuclease VIII-like 1 (NEIL1)]]
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== References ==
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*[[Fpg Nei Protein Family|Fpg Nei Protein Family]]
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015232006</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bandaru, V.]]
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[[Category: Large Structures]]
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[[Category: Bond, J P.]]
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[[Category: Bandaru V]]
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[[Category: Doublie, S.]]
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[[Category: Bond JP]]
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[[Category: Wallace, S S.]]
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[[Category: Doublie S]]
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[[Category: Helix two turns helix]]
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[[Category: Wallace SS]]
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[[Category: Hydrolase]]
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[[Category: Zinc-less finger]]
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Current revision

Crystal structure of human endonuclease VIII-like 1 (NEIL1)

PDB ID 1tdh

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