1tpc

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{{Seed}}
 
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[[Image:1tpc.png|left|200px]]
 
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==OFFSET OF A CATALYTIC LESION BY A BOUND WATER SOLUBLE==
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The line below this paragraph, containing "STRUCTURE_1tpc", creates the "Structure Box" on the page.
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<StructureSection load='1tpc' size='340' side='right'caption='[[1tpc]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tpc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TPC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGH:PHOSPHOGLYCOLOHYDROXAMIC+ACID'>PGH</scene></td></tr>
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{{STRUCTURE_1tpc| PDB=1tpc | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tpc OCA], [https://pdbe.org/1tpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tpc RCSB], [https://www.ebi.ac.uk/pdbsum/1tpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tpc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TPIS_CHICK TPIS_CHICK]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tp/1tpc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tpc ConSurf].
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<div style="clear:both"></div>
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===OFFSET OF A CATALYTIC LESION BY A BOUND WATER SOLUBLE===
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==See Also==
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*[[Triose phosphate isomerase 3D structures|Triose phosphate isomerase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_7577950}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7577950 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7577950}}
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==About this Structure==
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1TPC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPC OCA].
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==Reference==
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The structural basis for pseudoreversion of the E165D lesion by the secondary S96P mutation in triosephosphate isomerase depends on the positions of active site water molecules., Komives EA, Lougheed JC, Liu K, Sugio S, Zhang Z, Petsko GA, Ringe D, Biochemistry. 1995 Oct 17;34(41):13612-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7577950 7577950]
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Triose-phosphate isomerase]]
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[[Category: Knowles JR]]
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[[Category: Knowles, J R.]]
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[[Category: Komives EA]]
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[[Category: Komives, E A.]]
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[[Category: Liu KD]]
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[[Category: Liu, K D.]]
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[[Category: Petsko GA]]
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[[Category: Petsko, G A.]]
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[[Category: Ringe D]]
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[[Category: Ringe, D.]]
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[[Category: Sugio S]]
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[[Category: Sugio, S.]]
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[[Category: Zhang Z]]
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[[Category: Zhang, Z.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:38:00 2008''
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Current revision

OFFSET OF A CATALYTIC LESION BY A BOUND WATER SOLUBLE

PDB ID 1tpc

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