1tvg

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[[Image:1tvg.jpg|left|200px]]
 
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{{Structure
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==X-ray structure of human PP25 gene product, HSPC034. Northeast Structural Genomics Target HR1958.==
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|PDB= 1tvg |SIZE=350|CAPTION= <scene name='initialview01'>1tvg</scene>, resolution 1.60&Aring;
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<StructureSection load='1tvg' size='340' side='right'caption='[[1tvg]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene>
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<table><tr><td colspan='2'>[[1tvg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TVG FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00754 F5_F8_type_C]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tvg OCA], [https://pdbe.org/1tvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tvg RCSB], [https://www.ebi.ac.uk/pdbsum/1tvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tvg ProSAT], [https://www.topsan.org/Proteins/NESGC/1tvg TOPSAN]</span></td></tr>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tvg OCA], [http://www.ebi.ac.uk/pdbsum/1tvg PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1tvg RCSB]</span>
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</table>
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/IFT25_HUMAN IFT25_HUMAN] Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).
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'''X-ray structure of human PP25 gene product, HSPC034. Northeast Structural Genomics Target HR1958.'''
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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1TVG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVG OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tv/1tvg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tvg ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Acton, T B.]]
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[[Category: Acton TB]]
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[[Category: Hunt, J.]]
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[[Category: Hunt JF]]
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[[Category: Kuzin, A P.]]
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[[Category: Kuzin AP]]
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[[Category: Lee, I.]]
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[[Category: Lee I]]
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[[Category: Montelione, G T.]]
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[[Category: Montelione GT]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Tong L]]
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[[Category: Tong, L.]]
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[[Category: Vorobiev SM]]
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[[Category: Vorobiev, S M.]]
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[[Category: cell cycle]]
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[[Category: nesg]]
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[[Category: northeast structural genomics consortium]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 26 06:08:10 2008''
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Current revision

X-ray structure of human PP25 gene product, HSPC034. Northeast Structural Genomics Target HR1958.

PDB ID 1tvg

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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