1tvg

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{{Seed}}
 
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[[Image:1tvg.png|left|200px]]
 
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==X-ray structure of human PP25 gene product, HSPC034. Northeast Structural Genomics Target HR1958.==
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The line below this paragraph, containing "STRUCTURE_1tvg", creates the "Structure Box" on the page.
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<StructureSection load='1tvg' size='340' side='right'caption='[[1tvg]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tvg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TVG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene></td></tr>
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{{STRUCTURE_1tvg| PDB=1tvg | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tvg OCA], [https://pdbe.org/1tvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tvg RCSB], [https://www.ebi.ac.uk/pdbsum/1tvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tvg ProSAT], [https://www.topsan.org/Proteins/NESGC/1tvg TOPSAN]</span></td></tr>
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</table>
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===X-ray structure of human PP25 gene product, HSPC034. Northeast Structural Genomics Target HR1958.===
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== Function ==
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[https://www.uniprot.org/uniprot/IFT25_HUMAN IFT25_HUMAN] Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18816799}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18816799 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tv/1tvg_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18816799}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1TVG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TVG OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tvg ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:18816799</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Hunt, J F.]]
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[[Category: Acton TB]]
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[[Category: Kuzin, A P.]]
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[[Category: Hunt JF]]
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[[Category: Lee, I.]]
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[[Category: Kuzin AP]]
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[[Category: Montelione, G T.]]
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[[Category: Lee I]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Vorobiev, S M.]]
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[[Category: Vorobiev SM]]
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[[Category: Cell cycle]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 18:14:42 2009''
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Current revision

X-ray structure of human PP25 gene product, HSPC034. Northeast Structural Genomics Target HR1958.

PDB ID 1tvg

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OCA

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