1udh

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(New page: 200px<br /><applet load="1udh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1udh, resolution 1.75&Aring;" /> '''THE STRUCTURAL BASIS...)
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[[Image:1udh.gif|left|200px]]<br /><applet load="1udh" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1udh, resolution 1.75&Aring;" />
 
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'''THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE'''<br />
 
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==Overview==
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==THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE==
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The 1.75-A crystal structure of the uracil-DNA glycosylase from herpes, simplex virus type-1 reveals a new fold, distantly related to, dinucleotide-binding proteins. Complexes with a trideoxynucleotide, and, with uracil, define the DNA-binding site and allow a detailed, understanding of the exquisitely specific recognition of uracil in DNA., The overall structure suggests binding models for elongated single- and, double-stranded DNA substrates. Conserved residues close to the, uracil-binding site suggest a catalytic mechanism for hydrolytic base, excision.
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<StructureSection load='1udh' size='340' side='right'caption='[[1udh]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1udh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UDH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1udh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udh OCA], [https://pdbe.org/1udh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1udh RCSB], [https://www.ebi.ac.uk/pdbsum/1udh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1udh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UNG_HHV11 UNG_HHV11] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosine. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly, in terminally differentiated neurons which lack DNA repair enzymes.<ref>PMID:7552746</ref> <ref>PMID:16306042</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ud/1udh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1udh ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1UDH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with SO4 and URA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Uridine_nucleosidase Uridine nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.3 3.2.2.3] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UDH OCA].
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*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
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== References ==
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==Reference==
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<references/>
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The structural basis of specific base-excision repair by uracil-DNA glycosylase., Savva R, McAuley-Hecht K, Brown T, Pearl L, Nature. 1995 Feb 9;373(6514):487-93. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7845459 7845459]
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__TOC__
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[[Category: Human herpesvirus 4]]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Human alphaherpesvirus 1 strain 17]]
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[[Category: Uridine nucleosidase]]
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[[Category: Large Structures]]
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[[Category: Pearl, L.H.]]
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[[Category: Pearl LH]]
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[[Category: Savva, R.]]
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[[Category: Savva R]]
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[[Category: SO4]]
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[[Category: URA]]
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[[Category: hydrolase (dna-n-glycosidase)]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 04:02:31 2007''
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Current revision

THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE

PDB ID 1udh

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