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1up1

From Proteopedia

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[[Image:1up1.png|left|200px]]
 
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{{STRUCTURE_1up1| PDB=1up1 | SCENE= }}
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==UP1, THE TWO RNA-RECOGNITION MOTIF DOMAIN OF HNRNP A1==
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<StructureSection load='1up1' size='340' side='right'caption='[[1up1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===UP1, THE TWO RNA-RECOGNITION MOTIF DOMAIN OF HNRNP A1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1up1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UP1 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9115444}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1up1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1up1 OCA], [https://pdbe.org/1up1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1up1 RCSB], [https://www.ebi.ac.uk/pdbsum/1up1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1up1 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1up1]] is a 1 chain structure of [[Nucleoprotein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UP1 OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN] Amyotrophic lateral sclerosis;Inclusion body myopathy with Paget disease of bone and frontotemporal dementia. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref> The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23455423</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ROA1_HUMAN ROA1_HUMAN] Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.<ref>PMID:17229681</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/up/1up1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1up1 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Nucleoprotein|Nucleoprotein]]
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:009115444</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cheng, X.]]
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[[Category: Large Structures]]
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[[Category: Jokhan, L.]]
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[[Category: Cheng X]]
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[[Category: Krainer, A R.]]
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[[Category: Jokhan L]]
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[[Category: Mayeda, A.]]
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[[Category: Krainer AR]]
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[[Category: Xu, R M.]]
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[[Category: Mayeda A]]
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[[Category: Nuclear protein]]
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[[Category: Xu R-M]]
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[[Category: Nuclear proteinhnrnp a1]]
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[[Category: Rna-binding]]
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[[Category: Rna-recognition motif]]
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[[Category: Up1]]
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Current revision

UP1, THE TWO RNA-RECOGNITION MOTIF DOMAIN OF HNRNP A1

PDB ID 1up1

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