1vfr

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{{Seed}}
 
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[[Image:1vfr.png|left|200px]]
 
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==THE MAJOR NAD(P)H:FMN OXIDOREDUCTASE FROM VIBRIO FISCHERI==
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The line below this paragraph, containing "STRUCTURE_1vfr", creates the "Structure Box" on the page.
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<StructureSection load='1vfr' size='340' side='right'caption='[[1vfr]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vfr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aliivibrio_fischeri Aliivibrio fischeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VFR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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{{STRUCTURE_1vfr| PDB=1vfr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vfr OCA], [https://pdbe.org/1vfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vfr RCSB], [https://www.ebi.ac.uk/pdbsum/1vfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vfr ProSAT]</span></td></tr>
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</table>
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===THE MAJOR NAD(P)H:FMN OXIDOREDUCTASE FROM VIBRIO FISCHERI===
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== Function ==
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[https://www.uniprot.org/uniprot/FRA1_ALIFS FRA1_ALIFS] Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction. Major FMN reductase. It is capable of using both NADH and NADPH as electron donors. As electron acceptor, FMN is the most effective, FAD is considerably effective, and riboflavin is the least effective.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 9654450 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/1vfr_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_9654450}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1VFR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aliivibrio_fischeri Aliivibrio fischeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VFR OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vfr ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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1.8 A crystal structure of the major NAD(P)H:FMN oxidoreductase of a bioluminescent bacterium, Vibrio fischeri: overall structure, cofactor and substrate-analog binding, and comparison with related flavoproteins., Koike H, Sasaki H, Kobori T, Zenno S, Saigo K, Murphy ME, Adman ET, Tanokura M, J Mol Biol. 1998 Jul 10;280(2):259-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9654450 9654450]
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</StructureSection>
[[Category: Aliivibrio fischeri]]
[[Category: Aliivibrio fischeri]]
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[[Category: FMN reductase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Adman ET]]
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[[Category: Adman, E T.]]
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[[Category: Kobori T]]
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[[Category: Kobori, T.]]
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[[Category: Koike H]]
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[[Category: Koike, H.]]
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[[Category: Murphy MEP]]
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[[Category: Murphy, M E.P.]]
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[[Category: Saigo K]]
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[[Category: Saigo, K.]]
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[[Category: Sasaki H]]
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[[Category: Sasaki, H.]]
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[[Category: Tanokura M]]
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[[Category: Tanokura, M.]]
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[[Category: Zenno S]]
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[[Category: Zenno, S.]]
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[[Category: Bioluminescence]]
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[[Category: Fmn]]
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[[Category: Oxidoreductase]]
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[[Category: Vibrio fischeri]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:11:14 2008''
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Current revision

THE MAJOR NAD(P)H:FMN OXIDOREDUCTASE FROM VIBRIO FISCHERI

PDB ID 1vfr

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