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1vhr

From Proteopedia

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{{Seed}}
 
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[[Image:1vhr.png|left|200px]]
 
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<!--
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==HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE==
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The line below this paragraph, containing "STRUCTURE_1vhr", creates the "Structure Box" on the page.
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<StructureSection load='1vhr' size='340' side='right'caption='[[1vhr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vhr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VHR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1vhr| PDB=1vhr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vhr OCA], [https://pdbe.org/1vhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vhr RCSB], [https://www.ebi.ac.uk/pdbsum/1vhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vhr ProSAT]</span></td></tr>
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</table>
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===HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE===
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== Function ==
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[https://www.uniprot.org/uniprot/DUS3_HUMAN DUS3_HUMAN] Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.<ref>PMID:10224087</ref> <ref>PMID:11863439</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_8650541}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 8650541 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vh/1vhr_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_8650541}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1VHR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VHR OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vhr ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of the dual specificity protein phosphatase VHR., Yuvaniyama J, Denu JM, Dixon JE, Saper MA, Science. 1996 May 31;272(5266):1328-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8650541 8650541]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Denu JM]]
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[[Category: Denu, J M.]]
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[[Category: Dixon JE]]
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[[Category: Dixon, J E.]]
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[[Category: Saper MA]]
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[[Category: Saper, M A.]]
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[[Category: Yuvaniyama J]]
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[[Category: Yuvaniyama, J.]]
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[[Category: Hydrolase]]
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[[Category: Protein dual-specificity phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:05:25 2008''
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Current revision

HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE

PDB ID 1vhr

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