1vub

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[[Image:1vub.png|left|200px]]
 
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{{STRUCTURE_1vub| PDB=1vub | SCENE= }}
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==CCDB, A TOPOISOMERASE POISON FROM E. COLI==
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<StructureSection load='1vub' size='340' side='right'caption='[[1vub]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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===CCDB, A TOPOISOMERASE POISON FROM E. COLI===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1vub]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VUB FirstGlance]. <br>
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{{ABSTRACT_PUBMED_9917404}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vub OCA], [https://pdbe.org/1vub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vub RCSB], [https://www.ebi.ac.uk/pdbsum/1vub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vub ProSAT]</span></td></tr>
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[[1vub]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VUB OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/CCDB_ECOLI CCDB_ECOLI] Toxic component of a toxin-antitoxin (TA) module, functioning in plasmid maintainence. Responsible for the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Half-life of over 2 hours. Cell killing by CcdB is accompanied by filamentation, defects in chromosome and plasmid segregation, defects in cell division, formation of anucleate cells, decreased DNA synthesis and plasmid loss. Interferes with the activity of DNA gyrase, inducing it to form a covalent GyrA-DNA complex that cannot be resolved, thus promoting breakage of plasmid and chromosomal DNA. DNA breakage requires hydrolyzable ATP. Toxicity is inhibited by labile antitoxin CcdA, which blocks the activity of CcdB; CcdA also removes bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. Also acts to inhibit partitioning of the chromosomal DNA. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdA.<ref>PMID:6327993</ref> <ref>PMID:2651399</ref> <ref>PMID:6308648</ref> <ref>PMID:2615761</ref> <ref>PMID:1324324</ref> <ref>PMID:8604132</ref>
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<ref group="xtra">PMID:009917404</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vu/1vub_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vub ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Bahasi, E M.]]
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[[Category: Large Structures]]
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[[Category: Couturier, M.]]
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[[Category: Bahasi EM]]
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[[Category: Dao-Thi, M H.]]
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[[Category: Couturier M]]
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[[Category: Liddington, R.]]
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[[Category: Dao-Thi M-H]]
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[[Category: Loris, R.]]
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[[Category: Liddington R]]
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[[Category: Melderen, L Van.]]
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[[Category: Loris R]]
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[[Category: Poortmans, F.]]
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[[Category: Poortmans F]]
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[[Category: Wyns, L.]]
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[[Category: Van Melderen L]]
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[[Category: Ccdb]]
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[[Category: Wyns L]]
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[[Category: Plasmid addiction]]
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[[Category: Topoisomerase poison]]
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Current revision

CCDB, A TOPOISOMERASE POISON FROM E. COLI

PDB ID 1vub

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