1w8h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="1w8h" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w8h, resolution 1.75&Aring;" /> '''STRUCTURE OF PSEUDO...)
Current revision (08:47, 14 February 2024) (edit) (undo)
 
(23 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1w8h.gif|left|200px]]<br />
 
-
<applet load="1w8h" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1w8h, resolution 1.75&Aring;" />
 
-
'''STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) COMPLEXED WITH LEWISA TRISACCHARIDE'''<br />
 
-
==Overview==
+
==structure of pseudomonas aeruginosa lectin II (PA-IIL)complexed with lewisA trisaccharide==
-
One of the mechanisms contributing to the protection by breast-feeding of, the newborn against enteric diseases is related to the ability of human, milk oligosaccharides to prevent the attachment of pathogenic bacteria to, the duodenual epithelium. Indeed, a variety of fucosylated, oligosaccharides, specific to human milk, form part of the innate immune, system. In the present study, we demonstrate the specific blocking of, PA-IIL, a fucose-binding lectin of the human pathogen Pseudomonas, aeruginosa, by milk oligosaccharides. Two fucosylated epitopes, Lewis a, and 3-fucosyl-lactose (Lewis x glucose analogue) bind to the lectin with, dissociation constants of 2.2x10(-7) M and 3.6x10(-7) M respectively., Thermodynamic studies indicate that these interactions are dominated by, enthalpy. The ... [[http://ispc.weizmann.ac.il/pmbin/getpm?15790314 (full description)]]
+
<StructureSection load='1w8h' size='340' side='right'caption='[[1w8h]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1w8h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W8H FirstGlance]. <br>
-
1W8H is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with CA, SO4 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W8H OCA]].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w8h OCA], [https://pdbe.org/1w8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w8h RCSB], [https://www.ebi.ac.uk/pdbsum/1w8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w8h ProSAT]</span></td></tr>
-
Structural basis for the interaction between human milk oligosaccharides and the bacterial lectin PA-IIL of Pseudomonas aeruginosa., Perret S, Sabin C, Dumon C, Pokorna M, Gautier C, Galanina O, Ilia S, Bovin N, Nicaise M, Desmadril M, Gilboa-Garber N, Wimmerova M, Mitchell EP, Imberty A, Biochem J. 2005 Jul 15;389(Pt 2):325-32. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15790314 15790314]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q9HYN5_PSEAE Q9HYN5_PSEAE]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w8/1w8h_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w8h ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
-
[[Category: Single protein]]
+
[[Category: Bovin N]]
-
[[Category: Bovin, N.]]
+
[[Category: Budova M]]
-
[[Category: Budova, M.]]
+
[[Category: Desmadril M]]
-
[[Category: Desmadril, M.]]
+
[[Category: Dumon C]]
-
[[Category: Dumon, C.]]
+
[[Category: Galanina O]]
-
[[Category: Galanina, O.]]
+
[[Category: Gautier C]]
-
[[Category: Gautier, C.]]
+
[[Category: Gilboa-Garber N]]
-
[[Category: Gilboa-Garber, N.]]
+
[[Category: Ilia S]]
-
[[Category: Ilia, S.]]
+
[[Category: Imberty A]]
-
[[Category: Imberty, A.]]
+
[[Category: Mitchell EP]]
-
[[Category: Mitchell, E.P.]]
+
[[Category: Nicaise M]]
-
[[Category: Nicaise, M.]]
+
[[Category: Perret S]]
-
[[Category: Perret, S.]]
+
[[Category: Sabin C]]
-
[[Category: Sabin, C.]]
+
[[Category: Wimmerova M]]
-
[[Category: Wimmerova, M.]]
+
-
[[Category: CA]]
+
-
[[Category: GOL]]
+
-
[[Category: SO4]]
+
-
[[Category: cystic fibrosis]]
+
-
[[Category: lectin]]
+
-
[[Category: lewis a]]
+
-
[[Category: pseudomonas aeruginosa]]
+
-
[[Category: sugar]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 21:22:55 2007''
+

Current revision

structure of pseudomonas aeruginosa lectin II (PA-IIL)complexed with lewisA trisaccharide

PDB ID 1w8h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1w8h"
Personal tools