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1x7b
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| - | {{STRUCTURE_1x7b| PDB=1x7b | SCENE= }} | ||
| - | ===CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041=== | ||
| - | {{ABSTRACT_PUBMED_15548008}} | ||
| - | == | + | ==CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041== |
| - | [[http://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN | + | <StructureSection load='1x7b' size='340' side='right'caption='[[1x7b]], [[Resolution|resolution]] 2.30Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[1x7b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X7B FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=041:2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL'>041</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x7b OCA], [https://pdbe.org/1x7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x7b RCSB], [https://www.ebi.ac.uk/pdbsum/1x7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x7b ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x7/1x7b_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x7b ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Estrogen receptor|Estrogen receptor]] | + | *[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Akopian | + | [[Category: Large Structures]] |
| - | [[Category: Alvarez | + | [[Category: Akopian T]] |
| - | [[Category: Bapat | + | [[Category: Alvarez JC]] |
| - | [[Category: Bhat | + | [[Category: Bapat A]] |
| - | [[Category: Harris | + | [[Category: Bhat RA]] |
| - | [[Category: Hsiao | + | [[Category: Harris HA]] |
| - | [[Category: Hum | + | [[Category: Hsiao C]] |
| - | [[Category: Malakian | + | [[Category: Hum WT]] |
| - | [[Category: Malamas | + | [[Category: Malakian K]] |
| - | [[Category: Manas | + | [[Category: Malamas MS]] |
| - | [[Category: Miller | + | [[Category: Manas ES]] |
| - | [[Category: Somers | + | [[Category: Miller CP]] |
| - | [[Category: Stahl | + | [[Category: Somers WS]] |
| - | [[Category: Unwalla | + | [[Category: Stahl ML]] |
| - | [[Category: Wolfrom | + | [[Category: Unwalla RJ]] |
| - | [[Category: Xu | + | [[Category: Wolfrom S]] |
| - | + | [[Category: Xu ZB]] | |
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Current revision
CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041
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Categories: Homo sapiens | Large Structures | Akopian T | Alvarez JC | Bapat A | Bhat RA | Harris HA | Hsiao C | Hum WT | Malakian K | Malamas MS | Manas ES | Miller CP | Somers WS | Stahl ML | Unwalla RJ | Wolfrom S | Xu ZB
