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1xa6

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{{Seed}}
 
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[[Image:1xa6.png|left|200px]]
 
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<!--
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==Crystal Structure of the Human Beta2-Chimaerin==
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The line below this paragraph, containing "STRUCTURE_1xa6", creates the "Structure Box" on the page.
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<StructureSection load='1xa6' size='340' side='right'caption='[[1xa6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xa6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XA6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1xa6| PDB=1xa6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xa6 OCA], [https://pdbe.org/1xa6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xa6 RCSB], [https://www.ebi.ac.uk/pdbsum/1xa6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xa6 ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of the Human Beta2-Chimaerin===
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== Function ==
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[https://www.uniprot.org/uniprot/CHIO_HUMAN CHIO_HUMAN] GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15507211}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15507211 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/1xa6_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15507211}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1XA6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XA6 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xa6 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin., Canagarajah B, Leskow FC, Ho JY, Mischak H, Saidi LF, Kazanietz MG, Hurley JH, Cell. 2004 Oct 29;119(3):407-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15507211 15507211]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Canagarajah, B.]]
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[[Category: Canagarajah B]]
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[[Category: Ho, J Y.]]
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[[Category: Ho JY]]
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[[Category: Hurley, J H.]]
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[[Category: Hurley JH]]
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[[Category: Kazanietz, M G.]]
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[[Category: Kazanietz MG]]
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[[Category: Leskow, F C.]]
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[[Category: Leskow FC]]
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[[Category: Mischak, H.]]
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[[Category: Mischak H]]
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[[Category: Saidi, L F.]]
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[[Category: Saidi LF]]
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[[Category: Beta2-chimaerin]]
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[[Category: C1]]
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[[Category: Racgap]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:30:51 2008''
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Current revision

Crystal Structure of the Human Beta2-Chimaerin

PDB ID 1xa6

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