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1xdq

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{{Seed}}
 
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[[Image:1xdq.png|left|200px]]
 
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<!--
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==Structural and Biochemical Identification of a Novel Bacterial Oxidoreductase==
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The line below this paragraph, containing "STRUCTURE_1xdq", creates the "Structure Box" on the page.
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<StructureSection load='1xdq' size='340' side='right'caption='[[1xdq]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xdq]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XDQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MO:MOLYBDENUM+ATOM'>MO</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene>, <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
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{{STRUCTURE_1xdq| PDB=1xdq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xdq OCA], [https://pdbe.org/1xdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xdq RCSB], [https://www.ebi.ac.uk/pdbsum/1xdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xdq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MSRP_ECOLI MSRP_ECOLI] Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons (PubMed:26641313). Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine (PubMed:26641313). MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation, including the primary periplasmic chaperone SurA and the lipoprotein Pal (PubMed:26641313). The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide (PubMed:26641313). Can catalyze the reduction of a variety of substrates in vitro, including dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide (PubMed:15355966). Cannot reduce cyclic N-oxides (PubMed:15355966). Shows no activity as sulfite oxidase (PubMed:15355966).<ref>PMID:15355966</ref> <ref>PMID:26641313</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/1xdq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xdq ConSurf].
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<div style="clear:both"></div>
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===Structural and Biochemical Identification of a Novel Bacterial Oxidoreductase===
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==See Also==
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*[[Sulfite Oxidase|Sulfite Oxidase]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15355966}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15355966 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_15355966}}
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==About this Structure==
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1XDQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDQ OCA].
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==Reference==
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Structural and biochemical identification of a novel bacterial oxidoreductase., Loschi L, Brokx SJ, Hills TL, Zhang G, Bertero MG, Lovering AL, Weiner JH, Strynadka NC, J Biol Chem. 2004 Nov 26;279(48):50391-400. Epub 2004 Sep 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15355966 15355966]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bertero, M G.]]
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[[Category: Bertero MG]]
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[[Category: Brokx, S J.]]
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[[Category: Brokx SJ]]
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[[Category: Hills, T L.]]
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[[Category: Hills TL]]
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[[Category: Loschi, L.]]
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[[Category: Loschi L]]
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[[Category: Lovering, A L.]]
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[[Category: Lovering AL]]
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[[Category: Strynadka, N C.]]
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[[Category: Strynadka NC]]
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[[Category: Weiner, J H.]]
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[[Category: Weiner JH]]
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[[Category: Zhang, G.]]
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[[Category: Zhang G]]
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[[Category: Bioinformatic]]
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[[Category: Electron transfer]]
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[[Category: Molybdoenzyme]]
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[[Category: Molybdopterin]]
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[[Category: Oxidoreductase]]
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[[Category: Sequence analysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:27:15 2008''
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Current revision

Structural and Biochemical Identification of a Novel Bacterial Oxidoreductase

PDB ID 1xdq

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