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1xem

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{{Seed}}
 
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[[Image:1xem.png|left|200px]]
 
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<!--
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==High Resolution Crystal Structure of Escherichia coli Zinc- Peptide Deformylase bound to formate==
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The line below this paragraph, containing "STRUCTURE_1xem", creates the "Structure Box" on the page.
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<StructureSection load='1xem' size='340' side='right'caption='[[1xem]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XEM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1xem| PDB=1xem | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xem OCA], [https://pdbe.org/1xem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xem RCSB], [https://www.ebi.ac.uk/pdbsum/1xem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xem ProSAT]</span></td></tr>
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</table>
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===High Resolution Crystal Structure of Escherichia coli Zinc- Peptide Deformylase bound to formate===
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== Function ==
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[https://www.uniprot.org/uniprot/DEF_ECOLI DEF_ECOLI] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15796505}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15796505 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/1xem_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15796505}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1XEM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEM OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xem ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structures of E. coli peptide deformylase bound to formate: insight into the preference for Fe2+ over Zn2+ as the active site metal., Jain R, Hao B, Liu RP, Chan MK, J Am Chem Soc. 2005 Apr 6;127(13):4558-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15796505 15796505]
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Peptide deformylase]]
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[[Category: Chan MK]]
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[[Category: Single protein]]
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[[Category: Hao B]]
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[[Category: Chan, M K.]]
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[[Category: Jain R]]
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[[Category: Hao, B.]]
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[[Category: Liu R-P]]
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[[Category: Jain, R.]]
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[[Category: Liu, R P.]]
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[[Category: Formate]]
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[[Category: Zinc deformylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:58:52 2008''
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Current revision

High Resolution Crystal Structure of Escherichia coli Zinc- Peptide Deformylase bound to formate

PDB ID 1xem

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