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1xeq

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[[Image:1xeq.png|left|200px]]
 
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{{STRUCTURE_1xeq| PDB=1xeq | SCENE= }}
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==Crystal tructure of RNA binding domain of influenza B virus non-structural protein==
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<StructureSection load='1xeq' size='340' side='right'caption='[[1xeq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===Crystal tructure of RNA binding domain of influenza B virus non-structural protein===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xeq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Lee/1940) Influenza B virus (B/Lee/1940)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XEQ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_017475623}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xeq OCA], [https://pdbe.org/1xeq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xeq RCSB], [https://www.ebi.ac.uk/pdbsum/1xeq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xeq ProSAT], [https://www.topsan.org/Proteins/NESGC/1xeq TOPSAN]</span></td></tr>
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[[1xeq]] is a 2 chain structure of [[Nonstructural protein]] with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEQ OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref>
==See Also==
==See Also==
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*[[Nonstructural protein|Nonstructural protein]]
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*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017475623</ref><references group="xtra"/>
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__TOC__
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[[Category: Viruses]]
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</StructureSection>
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[[Category: Khan, J A.]]
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[[Category: Large Structures]]
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[[Category: Krug, R M.]]
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[[Category: Khan JA]]
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[[Category: Montelione, G T.]]
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[[Category: Krug RM]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Yin, C.]]
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[[Category: Yin C]]
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[[Category: Influenza b virus]]
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[[Category: Nesg]]
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[[Category: Non-structural protein]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Ns1b]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Rna binding domain]]
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[[Category: Structural genomic]]
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[[Category: Viral protein]]
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Current revision

Crystal tructure of RNA binding domain of influenza B virus non-structural protein

PDB ID 1xeq

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