1xks

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[[Image:1xks.gif|left|200px]]
 
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{{Structure
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==The crystal structure of the N-terminal domain of Nup133 reveals a beta-propeller fold common to several nucleoporins==
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|PDB= 1xks |SIZE=350|CAPTION= <scene name='initialview01'>1xks</scene>, resolution 2.35&Aring;
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<StructureSection load='1xks' size='340' side='right'caption='[[1xks]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1xks]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XKS FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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|GENE= NUP133 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xks OCA], [https://pdbe.org/1xks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xks RCSB], [https://www.ebi.ac.uk/pdbsum/1xks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xks ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xks OCA], [http://www.ebi.ac.uk/pdbsum/1xks PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xks RCSB]</span>
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[https://www.uniprot.org/uniprot/NU133_HUMAN NU133_HUMAN] Involved in poly(A)+ RNA transport.<ref>PMID:11684705</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xk/1xks_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xks ConSurf].
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<div style="clear:both"></div>
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'''The crystal structure of the N-terminal domain of Nup133 reveals a beta-propeller fold common to several nucleoporins'''
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==See Also==
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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== References ==
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==Overview==
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<references/>
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Nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs) whose complex architecture is generated from a set of only approximately 30 proteins, termed nucleoporins. Here, we explore the domain structure of Nup133, a nucleoporin in a conserved NPC subcomplex that is crucial for NPC biogenesis and is believed to form part of the NPC scaffold. We show that human Nup133 contains two domains: a COOH-terminal domain responsible for its interaction with its subcomplex through Nup107; and an NH2-terminal domain whose crystal structure reveals a seven-bladed beta-propeller. The surface properties and conservation of the Nup133 beta-propeller suggest it may mediate multiple interactions with other proteins. Other beta-propellers are predicted in a third of all nucleoporins. These and several other repeat-based motifs appear to be major elements of nucleoporins, indicating a level of structural repetition that may conceptually simplify the assembly and disassembly of this huge protein complex.
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__TOC__
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</StructureSection>
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==About this Structure==
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1XKS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKS OCA].
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==Reference==
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Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex., Berke IC, Boehmer T, Blobel G, Schwartz TU, J Cell Biol. 2004 Nov 22;167(4):591-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15557116 15557116]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Berke, I C.]]
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[[Category: Berke IC]]
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[[Category: Blobel, G.]]
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[[Category: Blobel G]]
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[[Category: Boehmer, T.]]
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[[Category: Boehmer T]]
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[[Category: Schwartz, T U.]]
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[[Category: Schwartz TU]]
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[[Category: beta-propeller]]
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[[Category: helical insertion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:50:59 2008''
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Current revision

The crystal structure of the N-terminal domain of Nup133 reveals a beta-propeller fold common to several nucleoporins

PDB ID 1xks

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