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1xkt

From Proteopedia

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{{Seed}}
 
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[[Image:1xkt.png|left|200px]]
 
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==Human fatty acid synthase: Structure and substrate selectivity of the thioesterase domain==
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The line below this paragraph, containing "STRUCTURE_1xkt", creates the "Structure Box" on the page.
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<StructureSection load='1xkt' size='340' side='right'caption='[[1xkt]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xkt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XKT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xkt OCA], [https://pdbe.org/1xkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xkt RCSB], [https://www.ebi.ac.uk/pdbsum/1xkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xkt ProSAT]</span></td></tr>
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{{STRUCTURE_1xkt| PDB=1xkt | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FAS_HUMAN FAS_HUMAN] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xk/1xkt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xkt ConSurf].
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<div style="clear:both"></div>
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===Human fatty acid synthase: Structure and substrate selectivity of the thioesterase domain===
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==See Also==
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*[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15507492}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15507492 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_15507492}}
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==About this Structure==
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1XKT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XKT OCA].
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==Reference==
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Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain., Chakravarty B, Gu Z, Chirala SS, Wakil SJ, Quiocho FA, Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15567-72. Epub 2004 Oct 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15507492 15507492]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chakravarty, B.]]
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[[Category: Chakravarty B]]
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[[Category: Chirala, S S.]]
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[[Category: Chirala SS]]
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[[Category: Gu, Z.]]
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[[Category: Gu Z]]
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[[Category: Quiocho, F A.]]
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[[Category: Quiocho FA]]
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[[Category: Wakil, S J.]]
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[[Category: Wakil SJ]]
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[[Category: Drug target]]
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[[Category: Human fatty acid synthase]]
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[[Category: Specificity]]
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[[Category: Structure]]
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[[Category: Thioesterase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:37:23 2008''
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Current revision

Human fatty acid synthase: Structure and substrate selectivity of the thioesterase domain

PDB ID 1xkt

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