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1xo5

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[[Image:1xo5.png|left|200px]]
 
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{{STRUCTURE_1xo5| PDB=1xo5 | SCENE= }}
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==Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein==
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<StructureSection load='1xo5' size='340' side='right'caption='[[1xo5]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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===Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xo5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XO5 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15574431}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xo5 OCA], [https://pdbe.org/1xo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xo5 RCSB], [https://www.ebi.ac.uk/pdbsum/1xo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xo5 ProSAT]</span></td></tr>
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[[1xo5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XO5 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/CIB1_HUMAN CIB1_HUMAN] May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.<ref>PMID:12714504</ref> <ref>PMID:12881299</ref> <ref>PMID:15685448</ref> <ref>PMID:18627437</ref> <ref>PMID:19805025</ref> <ref>PMID:21264284</ref>
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<ref group="xtra">PMID:015574431</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xo/1xo5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xo5 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Betts, L.]]
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[[Category: Large Structures]]
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[[Category: Ferrara, J D.]]
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[[Category: Betts L]]
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[[Category: Gentry, H R.]]
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[[Category: Ferrara JD]]
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[[Category: Parise, L V.]]
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[[Category: Gentry HR]]
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[[Category: Singer, A U.]]
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[[Category: Parise LV]]
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[[Category: Sondek, J.]]
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[[Category: Singer AU]]
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[[Category: Yang, C.]]
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[[Category: Sondek J]]
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[[Category: Calcium and integrin binding]]
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[[Category: Yang C]]
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[[Category: Calcium-binding protein]]
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[[Category: Calmyrin]]
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[[Category: Ef-hand]]
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[[Category: Kinase interacting protein]]
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Current revision

Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein

PDB ID 1xo5

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