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1xp0
From Proteopedia
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| - | [[Image:1xp0.png|left|200px]] | ||
| - | + | ==Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Vardenafil== | |
| - | + | <StructureSection load='1xp0' size='340' side='right'caption='[[1xp0]], [[Resolution|resolution]] 1.79Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1xp0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''cAMP-dependent Protein Kinase (PKA)'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_8 10.2210/rcsb_pdb/mom_2012_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XP0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VDN:2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE'>VDN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xp0 OCA], [https://pdbe.org/1xp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xp0 RCSB], [https://www.ebi.ac.uk/pdbsum/1xp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xp0 ProSAT]</span></td></tr> |
| - | [[1xp0]] is a 1 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xp/1xp0_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xp0 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Phosphodiesterase|Phosphodiesterase]] | + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | + | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Artis | + | [[Category: Large Structures]] |
| - | [[Category: Bollag | + | [[Category: RCSB PDB Molecule of the Month]] |
| - | [[Category: Card | + | [[Category: Artis DR]] |
| - | [[Category: England | + | [[Category: Bollag G]] |
| - | [[Category: Fong | + | [[Category: Card GL]] |
| - | [[Category: Gillette | + | [[Category: England BP]] |
| - | [[Category: Ibrahim | + | [[Category: Fong D]] |
| - | [[Category: Kim | + | [[Category: Gillette S]] |
| - | [[Category: Lee | + | [[Category: Ibrahim PN]] |
| - | [[Category: Luu | + | [[Category: Kim S-H]] |
| - | [[Category: Milburn | + | [[Category: Lee B]] |
| - | [[Category: Powell | + | [[Category: Luu C]] |
| - | [[Category: Schlessinger | + | [[Category: Milburn MV]] |
| - | [[Category: Suzuki | + | [[Category: Powell B]] |
| - | [[Category: Tabrizizad | + | [[Category: Schlessinger J]] |
| - | [[Category: Zhang | + | [[Category: Suzuki Y]] |
| - | + | [[Category: Tabrizizad M]] | |
| - | + | [[Category: Zhang KYJ]] | |
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Current revision
Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Vardenafil
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Categories: Homo sapiens | Large Structures | RCSB PDB Molecule of the Month | Artis DR | Bollag G | Card GL | England BP | Fong D | Gillette S | Ibrahim PN | Kim S-H | Lee B | Luu C | Milburn MV | Powell B | Schlessinger J | Suzuki Y | Tabrizizad M | Zhang KYJ
