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1xuz

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{{Seed}}
 
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[[Image:1xuz.png|left|200px]]
 
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<!--
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==Crystal structure analysis of sialic acid synthase (NeuB)from Neisseria meningitidis, bound to Mn2+, Phosphoenolpyruvate, and N-acetyl mannosaminitol==
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The line below this paragraph, containing "STRUCTURE_1xuz", creates the "Structure Box" on the page.
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<StructureSection load='1xuz' size='340' side='right'caption='[[1xuz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xuz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XUZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MMN:5-DEOXY-5-{[(1S)-1-HYDROXYETHYL]AMINO}-D-GLUCITOL'>MMN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEP:PHOSPHOENOLPYRUVATE'>PEP</scene></td></tr>
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{{STRUCTURE_1xuz| PDB=1xuz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xuz OCA], [https://pdbe.org/1xuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xuz RCSB], [https://www.ebi.ac.uk/pdbsum/1xuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xuz ProSAT]</span></td></tr>
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</table>
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===Crystal structure analysis of sialic acid synthase (NeuB)from Neisseria meningitidis, bound to Mn2+, Phosphoenolpyruvate, and N-acetyl mannosaminitol===
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== Function ==
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[https://www.uniprot.org/uniprot/Q57265_NEIME Q57265_NEIME]
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15516336}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15516336 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xu/1xuz_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15516336}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1XUZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUZ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xuz ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol., Gunawan J, Simard D, Gilbert M, Lovering AL, Wakarchuk WW, Tanner ME, Strynadka NC, J Biol Chem. 2005 Feb 4;280(5):3555-63. Epub 2004 Oct 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15516336 15516336]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Neisseria meningitidis]]
[[Category: Neisseria meningitidis]]
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[[Category: Single protein]]
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[[Category: Gilbert M]]
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[[Category: Gilbert, M.]]
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[[Category: Gunawan J]]
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[[Category: Gunawan, J.]]
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[[Category: Lovering AL]]
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[[Category: Lovering, A L.]]
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[[Category: Simard D]]
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[[Category: Simard, D.]]
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[[Category: Strynadka NC]]
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[[Category: Strynadka, N C.]]
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[[Category: Tanner ME]]
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[[Category: Tanner, M E.]]
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[[Category: Wakarchuk WW]]
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[[Category: Wakarchuk, W W.]]
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[[Category: Antifreeze-like domain]]
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[[Category: Domain-swapped dimer]]
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[[Category: Tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:44:28 2008''
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Current revision

Crystal structure analysis of sialic acid synthase (NeuB)from Neisseria meningitidis, bound to Mn2+, Phosphoenolpyruvate, and N-acetyl mannosaminitol

PDB ID 1xuz

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