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1xwf

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[[Image:1xwf.png|left|200px]]
 
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{{STRUCTURE_1xwf| PDB=1xwf | SCENE= }}
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==K185N mutated S-adenosylhomocysteine hydrolase==
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<StructureSection load='1xwf' size='340' side='right'caption='[[1xwf]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xwf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XWF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xwf OCA], [https://pdbe.org/1xwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xwf RCSB], [https://www.ebi.ac.uk/pdbsum/1xwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xwf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAHH_RAT SAHH_RAT] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xw/1xwf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xwf ConSurf].
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<div style="clear:both"></div>
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===K185N mutated S-adenosylhomocysteine hydrolase===
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==See Also==
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*[[S-adenosylhomocysteine hydrolase|S-adenosylhomocysteine hydrolase]]
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{{ABSTRACT_PUBMED_16061414}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1xwf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWF OCA].
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==Reference==
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<ref group="xtra">PMID:016061414</ref><references group="xtra"/>
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[[Category: Adenosylhomocysteinase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Fujioka, M.]]
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[[Category: Fujioka M]]
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[[Category: Gomi, T.]]
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[[Category: Gomi T]]
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[[Category: Komoto, J.]]
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[[Category: Komoto J]]
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[[Category: Ogawa, H.]]
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[[Category: Ogawa H]]
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[[Category: Takata, Y.]]
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[[Category: Takata Y]]
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[[Category: Takusagawa, F.]]
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[[Category: Takusagawa F]]
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[[Category: Yamada, T.]]
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[[Category: Yamada T]]
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[[Category: Adohcy hydrolase]]
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[[Category: Adohcyase]]
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[[Category: Hydrolase]]
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[[Category: S-adenosylhomocysteine hydrolase]]
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[[Category: Sahh]]
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Current revision

K185N mutated S-adenosylhomocysteine hydrolase

PDB ID 1xwf

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