1xyz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:54, 14 February 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1xyz.gif|left|200px]]
 
-
{{Structure
+
==A COMMON PROTEIN FOLD AND SIMILAR ACTIVE SITE IN TWO DISTINCT FAMILIES OF BETA-GLYCANASES==
-
|PDB= 1xyz |SIZE=350|CAPTION= <scene name='initialview01'>1xyz</scene>, resolution 1.4&Aring;
+
<StructureSection load='1xyz' size='340' side='right'caption='[[1xyz]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[1xyz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetivibrio_thermocellus Acetivibrio thermocellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XYZ FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyz OCA], [https://pdbe.org/1xyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xyz RCSB], [https://www.ebi.ac.uk/pdbsum/1xyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xyz ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xyz OCA], [http://www.ebi.ac.uk/pdbsum/1xyz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xyz RCSB]</span>
+
[https://www.uniprot.org/uniprot/XYNZ_ACET2 XYNZ_ACET2]
-
}}
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
'''A COMMON PROTEIN FOLD AND SIMILAR ACTIVE SITE IN TWO DISTINCT FAMILIES OF BETA-GLYCANASES'''
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xy/1xyz_consurf.spt"</scriptWhenChecked>
-
==Overview==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
The structure of Clostridium thermocellum endoglucanase CelC, a member of the largest cellulase family (family A), has been determined at 2.15 A resolution. The protein folds into an (alpha/beta)8 barrel, with a deep active-site cleft generated by the insertion of a helical subdomain. The structure of the catalytic core of xylanase XynZ, which belongs to xylanase family F, has been determined at 1.4 A resolution. In spite of significant differences in substrate specificity and structure (including the absence of the helical subdomain), the general polypeptide folding pattern, architecture of the active site and catalytic mechanism of XynZ and CelC are similar, suggesting a common evolutionary origin.
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==About this Structure==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xyz ConSurf].
-
1XYZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_thermocellum Clostridium thermocellum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XYZ OCA].
+
<div style="clear:both"></div>
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
A common protein fold and similar active site in two distinct families of beta-glycanases., Dominguez R, Souchon H, Spinelli S, Dauter Z, Wilson KS, Chauvaux S, Beguin P, Alzari PM, Nat Struct Biol. 1995 Jul;2(7):569-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7664125 7664125]
+
[[Category: Acetivibrio thermocellus]]
-
[[Category: Clostridium thermocellum]]
+
[[Category: Large Structures]]
-
[[Category: Endo-1,4-beta-xylanase]]
+
[[Category: Alzari PM]]
-
[[Category: Single protein]]
+
[[Category: Dominguez R]]
-
[[Category: Alzari, P M.]]
+
[[Category: Spinelli S]]
-
[[Category: Dominguez, R.]]
+
-
[[Category: Spinelli, S.]]
+
-
[[Category: clostridium thermocellum]]
+
-
[[Category: family f/10 of glycosyl hydrolase]]
+
-
[[Category: glycosyl hydrolase]]
+
-
[[Category: xylanase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:56:36 2008''
+

Current revision

A COMMON PROTEIN FOLD AND SIMILAR ACTIVE SITE IN TWO DISTINCT FAMILIES OF BETA-GLYCANASES

PDB ID 1xyz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xyz"
Personal tools