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1y0h

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(New page: 200px<br /><applet load="1y0h" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y0h, resolution 1.600&Aring;" /> '''Structure of Rv0793...)
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[[Image:1y0h.gif|left|200px]]<br /><applet load="1y0h" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1y0h, resolution 1.600&Aring;" />
 
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'''Structure of Rv0793 from Mycobacterium tuberculosis'''<br />
 
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==Overview==
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==Structure of Rv0793 from Mycobacterium tuberculosis==
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Mycobacterium tuberculosis infects millions worldwide. The Structural, Genomics Consortium for M. tuberculosis has targeted all genes from this, bacterium in hopes of discovering and developing new therapeutic agents., Open reading frame Rv0793 from M. tuberculosis was annotated with an, unknown function. The 3-dimensional structure of Rv0793 has been solved to, 1.6 A resolution. Its structure is very similar to that of Streptomyces, coelicolor ActVA-Orf6, a monooxygenase that participates in tailoring of, polyketide antibiotics in the absence of a cofactor. It is also similar to, the recently solved structure of YgiN, a quinol monooxygenase from, Escherichia coli. In addition, the structure of Rv0793 is similar to, several structures of other proteins with unknown function. These latter, structures have been determined recently as a result of structural genomic, projects for various bacterial species. In M. tuberculosis, Rv0793 and its, homologs may represent a class of monooygenases acting as reactive oxygen, species scavengers that are essential for evading host defenses. Since the, most prevalent mode of attack by the host defense on M. tuberculosis is by, reactive oxygen species and reactive nitrogen species, Rv0793 may provide, a novel target to combat infection by M. tuberculosis.
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<StructureSection load='1y0h' size='340' side='right'caption='[[1y0h]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1y0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y0H FirstGlance]. <br>
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1Y0H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with ACT as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Y0H OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0h OCA], [https://pdbe.org/1y0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y0h RCSB], [https://www.ebi.ac.uk/pdbsum/1y0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0h ProSAT], [https://www.topsan.org/Proteins/TBSGC/1y0h TOPSAN]</span></td></tr>
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The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis., Lemieux MJ, Ference C, Cherney MM, Wang M, Garen C, James MN, J Struct Funct Genomics. 2005 Dec;6(4):245-57. Epub 2006 Feb 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16496224 16496224]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Y0793_MYCTU Y0793_MYCTU] Putative monooygenase that might be involved in antibiotic biosynthesis, or may act as reactive oxygen species scavenger that could help in evading host defenses.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y0/1y0h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y0h ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Cherney MM]]
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[[Category: Cherney, M.M.]]
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[[Category: Ference C]]
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[[Category: Ference, C.]]
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[[Category: Garen C]]
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[[Category: Garen, C.]]
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[[Category: James MN]]
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[[Category: James, M.N.]]
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[[Category: Lemieux MJ]]
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[[Category: Lemieux, M.J.]]
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[[Category: Wang M]]
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[[Category: TBSGC, TB.Structural.Genomics.Consortium.]]
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[[Category: Wang, M.]]
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[[Category: ACT]]
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[[Category: alpha+beta sandwich with antiparallel beta-sheet]]
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[[Category: ferredoxin-like fold]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: tb structural genomics consortium]]
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[[Category: tbsgc]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:16:43 2007''
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Current revision

Structure of Rv0793 from Mycobacterium tuberculosis

PDB ID 1y0h

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