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1y0q

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(New page: 200px<br /><applet load="1y0q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y0q, resolution 3.60&Aring;" /> '''Crystal structure of...)
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[[Image:1y0q.gif|left|200px]]<br /><applet load="1y0q" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1y0q, resolution 3.60&Aring;" />
 
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'''Crystal structure of an active group I ribozyme-product complex'''<br />
 
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==Overview==
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==Crystal structure of an active group I ribozyme-product complex==
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Group I introns are catalytic RNAs capable of orchestrating two sequential, phosphotransesterification reactions that result in self-splicing. To, understand how the group I intron active site facilitates catalysis, we, have solved the structure of an active ribozyme derived from the orf142-I2, intron from phage Twort bound to a four-nucleotide product RNA at a, resolution of 3.6 A. In addition to the three conserved domains, characteristic of all group I introns, the Twort ribozyme has peripheral, insertions characteristic of phage introns. These elements form a ring, that completely envelops the active site, where a snug pocket for, guanosine is formed by a series of stacked base triples. The structure of, the active site reveals three potential binding sites for catalytic, metals, and invokes a role for the 2' hydroxyl of the guanosine substrate, in organization of the active site for catalysis.
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<StructureSection load='1y0q' size='340' side='right'caption='[[1y0q]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1y0q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_virus_Twort Staphylococcus virus Twort]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y0Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SPK:SPERMINE+(FULLY+PROTONATED+FORM)'>SPK</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0q OCA], [https://pdbe.org/1y0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y0q RCSB], [https://www.ebi.ac.uk/pdbsum/1y0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0q ProSAT]</span></td></tr>
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</table>
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==About this Structure==
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==See Also==
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1Y0Q is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Staphylococcus_phage_twort Staphylococcus phage twort] with SPK, MG and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Y0Q OCA].
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*[[Ribozyme 3D structures|Ribozyme 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of a phage Twort group I ribozyme-product complex., Golden BL, Kim H, Chase E, Nat Struct Mol Biol. 2005 Jan;12(1):82-9. Epub 2004 Dec 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15580277 15580277]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Staphylococcus virus Twort]]
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[[Category: Staphylococcus phage twort]]
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[[Category: Chase E]]
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[[Category: Chase, E.]]
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[[Category: Golden BL]]
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[[Category: Golden, B.L.]]
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[[Category: Kim H]]
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[[Category: Kim, H.]]
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[[Category: MG]]
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[[Category: SO4]]
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[[Category: SPK]]
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[[Category: guanosine-binding]]
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[[Category: ribozyme]]
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[[Category: rna-folding]]
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[[Category: rna-splicing]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:17:38 2007''
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Current revision

Crystal structure of an active group I ribozyme-product complex

PDB ID 1y0q

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