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1y0m
From Proteopedia
(Difference between revisions)
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<StructureSection load='1y0m' size='340' side='right'caption='[[1y0m]], [[Resolution|resolution]] 1.20Å' scene=''> | <StructureSection load='1y0m' size='340' side='right'caption='[[1y0m]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1y0m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1y0m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y0M FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2Å</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0m OCA], [https://pdbe.org/1y0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y0m RCSB], [https://www.ebi.ac.uk/pdbsum/1y0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0m ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y0m OCA], [https://pdbe.org/1y0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y0m RCSB], [https://www.ebi.ac.uk/pdbsum/1y0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y0m ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PLCG1_RAT PLCG1_RAT] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buffalo rat]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: Mariuzza | + | [[Category: Mariuzza R]] |
| - | [[Category: Sangwoo | + | [[Category: Sangwoo C]] |
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Current revision
Crystal structure of of the SH3 domain of phospholipase C Gamma-1
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