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1y26

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[[Image:1y26.gif|left|200px]]
 
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{{Structure
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==A-riboswitch-adenine complex==
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|PDB= 1y26 |SIZE=350|CAPTION= <scene name='initialview01'>1y26</scene>, resolution 2.10&Aring;
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<StructureSection load='1y26' size='340' side='right'caption='[[1y26]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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<table><tr><td colspan='2'>[[1y26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_vulnificus Vibrio vulnificus]. The October 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Riboswitches'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_10 10.2210/rcsb_pdb/mom_2010_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y26 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y26 OCA], [https://pdbe.org/1y26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y26 RCSB], [https://www.ebi.ac.uk/pdbsum/1y26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y26 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1y27|1Y27]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y26 OCA], [http://www.ebi.ac.uk/pdbsum/1y26 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1y26 RCSB]</span>
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}}
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'''A-riboswitch-adenine complex'''
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==See Also==
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*[[Riboswitch|Riboswitch]]
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*[[Riboswitch 3D structures|Riboswitch 3D structures]]
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==Overview==
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__TOC__
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Metabolite-sensing mRNAs, or "riboswitches," specifically interact with small ligands and direct expression of the genes involved in their metabolism. Riboswitches contain sensing "aptamer" modules, capable of ligand-induced structural changes, and downstream regions, harboring expression-controlling elements. We report the crystal structures of the add A-riboswitch and xpt G-riboswitch aptamer modules that distinguish between bound adenine and guanine with exquisite specificity and modulate expression of two different sets of genes. The riboswitches form tuning fork-like architectures, in which the prongs are held in parallel through hairpin loop interactions, and the internal bubble zippers up to form the purine binding pocket. The bound purines are held by hydrogen bonding interactions involving conserved nucleotides along their entire periphery. Recognition specificity is associated with Watson-Crick pairing of the encapsulated adenine and guanine ligands with uridine and cytosine, respectively.
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</StructureSection>
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: RCSB PDB Molecule of the Month]]
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1Y26 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Vibrio_vulnificus Vibrio vulnificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y26 OCA].
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[[Category: Riboswitches]]
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==Reference==
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Structural basis for discriminative regulation of gene expression by adenine- and guanine-sensing mRNAs., Serganov A, Yuan YR, Pikovskaya O, Polonskaia A, Malinina L, Phan AT, Hobartner C, Micura R, Breaker RR, Patel DJ, Chem Biol. 2004 Dec;11(12):1729-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15610857 15610857]
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[[Category: Protein complex]]
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[[Category: Vibrio vulnificus]]
[[Category: Vibrio vulnificus]]
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[[Category: Patel, D J.]]
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[[Category: Patel DJ]]
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[[Category: Serganov, A.]]
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[[Category: Serganov A]]
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[[Category: Yuan, Y R.]]
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[[Category: Yuan YR]]
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[[Category: a-riboswitch adenine recognition]]
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[[Category: crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:57:49 2008''
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Current revision

A-riboswitch-adenine complex

PDB ID 1y26

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