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1y5m

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[[Image:1y5m.png|left|200px]]
 
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{{STRUCTURE_1y5m| PDB=1y5m | SCENE= }}
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==The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes==
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<StructureSection load='1y5m' size='340' side='right'caption='[[1y5m]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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===The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1y5m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y5M FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15865440}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=OCT:N-OCTANE'>OCT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y5m OCA], [https://pdbe.org/1y5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y5m RCSB], [https://www.ebi.ac.uk/pdbsum/1y5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y5m ProSAT]</span></td></tr>
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[[1y5m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y5M OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y5/1y5m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y5m ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]]
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015865440</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: 11-beta-hydroxysteroid dehydrogenase]]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Clogston, C L.]]
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[[Category: Clogston CL]]
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[[Category: Delaney, J M.]]
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[[Category: Delaney JM]]
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[[Category: Jordan, S R.]]
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[[Category: Jordan SR]]
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[[Category: Nybo, R E.]]
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[[Category: Nybo RE]]
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[[Category: Osslund, T D.]]
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[[Category: Osslund TD]]
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[[Category: Plant, M H.]]
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[[Category: Plant MH]]
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[[Category: Xiong, F.]]
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[[Category: Xiong F]]
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[[Category: Zhang, J.]]
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[[Category: Zhang J]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]
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Current revision

The crystal structure of murine 11b-hydroxysteroid dehydrogenase: an important therapeutic target for diabetes

PDB ID 1y5m

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