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1yb1

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[[Image:1yb1.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI==
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|PDB= 1yb1 |SIZE=350|CAPTION= <scene name='initialview01'>1yb1</scene>, resolution 1.95&Aring;
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<StructureSection load='1yb1' size='340' side='right'caption='[[1yb1]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=AE2:AETIOCHOLANOLONE'>AE2</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[1yb1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YB1 FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Estradiol_17-beta-dehydrogenase Estradiol 17-beta-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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|GENE= DHRS8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AOI:ANDROSTERONE'>AOI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yb1 OCA], [https://pdbe.org/1yb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yb1 RCSB], [https://www.ebi.ac.uk/pdbsum/1yb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yb1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DHB11_HUMAN DHB11_HUMAN] Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yb/1yb1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yb1 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI'''
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==See Also==
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*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1YB1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YB1 OCA].
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[[Category: Estradiol 17-beta-dehydrogenase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bray, J.]]
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[[Category: Bray J]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi G]]
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[[Category: Delft, F Von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Kavanagh K]]
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[[Category: Kavanagh, K.]]
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[[Category: Lukacik P]]
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[[Category: Lukacik, P.]]
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[[Category: Ng S]]
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[[Category: Ng, S.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Sundstrom M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Von Delft F]]
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[[Category: Sundstrom, M.]]
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[[Category: AE2]]
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[[Category: CL]]
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[[Category: GOL]]
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[[Category: SO4]]
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[[Category: human]]
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[[Category: hydroxysteroid dehydrogenase]]
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[[Category: sgc]]
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[[Category: short chain dehydrogenase]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:20:45 2008''
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Current revision

Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI

PDB ID 1yb1

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