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1yrx

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[[Image:1yrx.gif|left|200px]]
 
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==Structure of a novel photoreceptor: the BLUF domain of AppA from Rhodobacter sphaeroides==
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The line below this paragraph, containing "STRUCTURE_1yrx", creates the "Structure Box" on the page.
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<StructureSection load='1yrx' size='340' side='right'caption='[[1yrx]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1yrx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides_2.4.1 Cereibacter sphaeroides 2.4.1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YRX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D9G:N-DODECYL-N,N-DIMETHYLGLYCINATE'>D9G</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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{{STRUCTURE_1yrx| PDB=1yrx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yrx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yrx OCA], [https://pdbe.org/1yrx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yrx RCSB], [https://www.ebi.ac.uk/pdbsum/1yrx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yrx ProSAT]</span></td></tr>
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</table>
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'''Structure of a novel photoreceptor: the BLUF domain of AppA from Rhodobacter sphaeroides'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q53119_CERSP Q53119_CERSP]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The flavin-binding BLUF domain of AppA represents a new class of blue light photoreceptors that are present in a number of bacterial and algal species. The dark state X-ray structure of this domain was determined at 2.3 A resolution. The domain demonstrates a new function for the common ferredoxin-like fold; two long alpha-helices flank the flavin, which is bound with its isoalloxazine ring perpendicular to a five-stranded beta-sheet. The hydrogen bond network and the overall protein topology of the BLUF domain (but not its sequence) bear some resemblance to LOV domains, a subset of PAS domains widely involved in signaling. Nearly all residues conserved in BLUF domains surround the flavin chromophore, many of which are involved in an intricate hydrogen bond network. Photoactivation may induce a rearrangement in this network via reorientation of the Gln63 side chain to form a new hydrogen bond to the flavin O4 position. This shift would also break a hydrogen bond to the Trp104 side chain, which may be critical in induction of global structural change in AppA.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yr/1yrx_consurf.spt"</scriptWhenChecked>
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1YRX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRX OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Structure of a novel photoreceptor, the BLUF domain of AppA from Rhodobacter sphaeroides., Anderson S, Dragnea V, Masuda S, Ybe J, Moffat K, Bauer C, Biochemistry. 2005 Jun 7;44(22):7998-8005. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15924418 15924418]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yrx ConSurf].
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[[Category: Rhodobacter sphaeroides]]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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[[Category: Anderson, S.]]
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</StructureSection>
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[[Category: Bauer, C.]]
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[[Category: Cereibacter sphaeroides 2 4.1]]
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[[Category: Dragnea, V.]]
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[[Category: Large Structures]]
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[[Category: Masuda, S.]]
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[[Category: Anderson S]]
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[[Category: Moffat, K.]]
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[[Category: Bauer C]]
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[[Category: Ybe, J.]]
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[[Category: Dragnea V]]
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[[Category: Ferredoxin-like fold]]
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[[Category: Masuda S]]
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[[Category: Flavin binding]]
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[[Category: Moffat K]]
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[[Category: Photoreceptor]]
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[[Category: Ybe J]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:42:28 2008''
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Current revision

Structure of a novel photoreceptor: the BLUF domain of AppA from Rhodobacter sphaeroides

PDB ID 1yrx

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