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1yt1

From Proteopedia

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[[Image:1yt1.png|left|200px]]
 
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{{STRUCTURE_1yt1| PDB=1yt1 | SCENE= }}
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==Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL==
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<StructureSection load='1yt1' size='340' side='right'caption='[[1yt1]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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===Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yt1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YT1 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15951571}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yt1 OCA], [https://pdbe.org/1yt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yt1 RCSB], [https://www.ebi.ac.uk/pdbsum/1yt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yt1 ProSAT]</span></td></tr>
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[[1yt1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YT1 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yt/1yt1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yt1 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Endoplasmin|Endoplasmin]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:015951571</ref><references group="xtra"/>
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[[Category: Canis lupus familiaris]]
[[Category: Canis lupus familiaris]]
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[[Category: Dollins, D E.]]
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[[Category: Large Structures]]
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[[Category: Gewirth, D T.]]
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[[Category: Dollins DE]]
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[[Category: Immormino, R M.]]
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[[Category: Gewirth DT]]
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[[Category: Bergerat]]
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[[Category: Immormino RM]]
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[[Category: Chaperone]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Gp96]]
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[[Category: Grp94]]
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[[Category: Hsp90]]
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[[Category: Htpg]]
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Current revision

Crystal Structure of the Unliganded Form of GRP94, the ER Hsp90: Basis for Nucleotide-Induced Conformational Change, GRP94N(DELTA)41 APO CRYSTAL

PDB ID 1yt1

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OCA

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