1yu0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:59, 14 February 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1yu0.gif|left|200px]]<br /><applet load="1yu0" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1yu0, resolution 1.56&Aring;" />
 
-
'''Major Tropism Determinant P1 Variant'''<br />
 
-
==Overview==
+
==Major Tropism Determinant P1 Variant==
-
Only few instances are known of protein folds that tolerate massive sequence variation for the sake of binding diversity. The most extensively characterized is the immunoglobulin fold. We now add to this the C-type lectin (CLec) fold, as found in the major tropism determinant (Mtd), a retroelement-encoded receptor-binding protein of Bordetella bacteriophage. Variation in Mtd, with its approximately 10(13) possible sequences, enables phage adaptation to Bordetella spp. Mtd is an intertwined, pyramid-shaped trimer, with variable residues organized by its CLec fold into discrete receptor-binding sites. The CLec fold provides a highly static scaffold for combinatorial display of variable residues, probably reflecting a different evolutionary solution for balancing diversity against stability from that in the immunoglobulin fold. Mtd variants are biased toward the receptor pertactin, and there is evidence that the CLec fold is used broadly for sequence variation by related retroelements.
+
<StructureSection load='1yu0' size='340' side='right'caption='[[1yu0]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1yu0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bordetella_virus_BPP1 Bordetella virus BPP1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YU0 FirstGlance]. <br>
-
1YU0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bordetella_phage_bpp-1 Bordetella phage bpp-1] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YU0 OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yu0 OCA], [https://pdbe.org/1yu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yu0 RCSB], [https://www.ebi.ac.uk/pdbsum/1yu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yu0 ProSAT]</span></td></tr>
-
The C-type lectin fold as an evolutionary solution for massive sequence variation., McMahon SA, Miller JL, Lawton JA, Kerkow DE, Hodes A, Marti-Renom MA, Doulatov S, Narayanan E, Sali A, Miller JF, Ghosh P, Nat Struct Mol Biol. 2005 Oct;12(10):886-92. Epub 2005 Sep 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16170324 16170324]
+
</table>
-
[[Category: Bordetella phage bpp-1]]
+
== Function ==
-
[[Category: Single protein]]
+
[https://www.uniprot.org/uniprot/FIBD_BPBPP FIBD_BPBPP] Tail fiber protein located at the distal ends of the fibers that binds to the adhesion receptors on the host surface, thereby determining the host range. The phage can alter its tropism by modifying this protein. Variants are expressed through a diversity-generating retroelement (DGR) that creates mutant copies of a template repeat and replaces the end of the tail fiber receptor-binding protein with these sequences, thus changing the host range. Milliards of variants of the fiber receptor-binding protein can be created with this system.<ref>PMID:15386016</ref>
-
[[Category: Ghosh, P.]]
+
== References ==
-
[[Category: Lawton, J A.]]
+
<references/>
-
[[Category: McMahon, S A.]]
+
__TOC__
-
[[Category: Miller, J L.]]
+
</StructureSection>
-
[[Category: CA]]
+
[[Category: Bordetella virus BPP1]]
-
[[Category: beta prism]]
+
[[Category: Large Structures]]
-
[[Category: beta sandwich]]
+
[[Category: Ghosh P]]
-
[[Category: c-type lectin]]
+
[[Category: Lawton JA]]
-
[[Category: diversity-generating retroelement]]
+
[[Category: McMahon SA]]
-
[[Category: variability]]
+
[[Category: Miller JL]]
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:09:04 2008''
+

Current revision

Major Tropism Determinant P1 Variant

PDB ID 1yu0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yu0"
Personal tools