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1z21

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[[Image:1z21.gif|left|200px]]
 
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==Crystal structure of the core domain of Yersinia pestis virulence factor YopR==
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The line below this paragraph, containing "STRUCTURE_1z21", creates the "Structure Box" on the page.
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<StructureSection load='1z21' size='340' side='right'caption='[[1z21]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1z21]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z21 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.499&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z21 OCA], [https://pdbe.org/1z21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z21 RCSB], [https://www.ebi.ac.uk/pdbsum/1z21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z21 ProSAT]</span></td></tr>
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{{STRUCTURE_1z21| PDB=1z21 | SCENE= }}
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</table>
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== Function ==
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'''Crystal structure of the core domain of Yersinia pestis virulence factor YopR'''
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[https://www.uniprot.org/uniprot/YSCH_YERPE YSCH_YERPE] Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Yersinia pestis, the causative agent of the plague, employs a type III secretion system (T3SS) to secrete and translocate virulence factors into to the cytoplasm of mammalian host cells. One of the secreted virulence factors is YopR. Little is known about the function of YopR other than that it is secreted into the extracellular milieu during the early stages of infection and that it contributes to virulence. Hoping to gain some insight into the function of YopR, we determined the crystal structure of its protease-resistant core domain, which consists of residues 38-149 out of 165 amino acids. The core domain is composed of five alpha-helices that display unexpected structural similarity with one domain of YopN, a central regulator of type III secretion in Y. pestis. This finding raises the possibility that YopR may play a role in the regulation of type III secretion.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/1z21_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1Z21 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z21 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z21 ConSurf].
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Crystal structure of the protease-resistant core domain of Yersinia pestis virulence factor YopR., Schubot FD, Cherry S, Austin BP, Tropea JE, Waugh DS, Protein Sci. 2005 Jun;14(6):1679-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15930010 15930010]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Yersinia pestis]]
[[Category: Yersinia pestis]]
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[[Category: Austin, B P.]]
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[[Category: Austin BP]]
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[[Category: Cherry, S.]]
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[[Category: Cherry S]]
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[[Category: Schubot, F D.]]
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[[Category: Schubot FD]]
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[[Category: Tropea, J E.]]
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[[Category: Tropea JE]]
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[[Category: Waugh, D S.]]
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[[Category: Waugh DS]]
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[[Category: Plague]]
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[[Category: Type iii secretion]]
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[[Category: Yersinia pesti]]
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[[Category: Yop]]
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[[Category: Yopr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:05:27 2008''
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Current revision

Crystal structure of the core domain of Yersinia pestis virulence factor YopR

PDB ID 1z21

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