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1z2m

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{{STRUCTURE_1z2m| PDB=1z2m | SCENE= }}
 
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===Crystal Structure of ISG15, the Interferon-Induced Ubiquitin Cross Reactive Protein===
 
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{{ABSTRACT_PUBMED_15917233}}
 
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==About this Structure==
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==Crystal Structure of ISG15, the Interferon-Induced Ubiquitin Cross Reactive Protein==
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[[1z2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2M OCA].
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<StructureSection load='1z2m' size='340' side='right'caption='[[1z2m]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==See Also==
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<table><tr><td colspan='2'>[[1z2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z2M FirstGlance]. <br>
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*[[Ubiquitin chains|Ubiquitin chains]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OS4:OSMIUM+4++ION'>OS4</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z2m OCA], [https://pdbe.org/1z2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z2m RCSB], [https://www.ebi.ac.uk/pdbsum/1z2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z2m ProSAT]</span></td></tr>
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<ref group="xtra">PMID:015917233</ref><references group="xtra"/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISG15_HUMAN ISG15_HUMAN] Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections.<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref> In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy (By similarity).<ref>PMID:1373138</ref> <ref>PMID:7526157</ref> <ref>PMID:8550581</ref> <ref>PMID:2005397</ref> <ref>PMID:16254333</ref> <ref>PMID:16009940</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/1z2m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z2m ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fu, Z.]]
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[[Category: Large Structures]]
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[[Category: Haas, A L.]]
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[[Category: Fu Z]]
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[[Category: Kim, J J.]]
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[[Category: Haas AL]]
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[[Category: Klein, J M.]]
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[[Category: Kim JJ]]
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[[Category: Narasimhan, J.]]
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[[Category: Klein JM]]
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[[Category: Wang, M.]]
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[[Category: Narasimhan J]]
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[[Category: Isg15]]
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[[Category: Wang M]]
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[[Category: Signaling protein]]
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[[Category: Ubiquitin cross reactive protein]]
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Current revision

Crystal Structure of ISG15, the Interferon-Induced Ubiquitin Cross Reactive Protein

PDB ID 1z2m

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