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1zdu

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{{STRUCTURE_1zdu| PDB=1zdu | SCENE= }}
 
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===The Crystal Structure of Human Liver Receptor Homologue-1===
 
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{{ABSTRACT_PUBMED_15897460}}
 
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==Disease==
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==The Crystal Structure of Human Liver Receptor Homologue-1==
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[[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
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<StructureSection load='1zdu' size='340' side='right'caption='[[1zdu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zdu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZDU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P3A:PHOSPHATIDYLGLYCEROL-PHOSPHOGLYCEROL'>P3A</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zdu OCA], [https://pdbe.org/1zdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zdu RCSB], [https://www.ebi.ac.uk/pdbsum/1zdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zdu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zd/1zdu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zdu ConSurf].
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<div style="clear:both"></div>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN]] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. [[http://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
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*[[Liver receptor homolog-1|Liver receptor homolog-1]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[1zdu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZDU OCA].
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==Reference==
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<ref group="xtra">PMID:015897460</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Eng, K.]]
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[[Category: Large Structures]]
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[[Category: Krupka, H I.]]
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[[Category: Eng K]]
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[[Category: Marimuthu, A.]]
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[[Category: Krupka HI]]
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[[Category: Mehra, U.]]
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[[Category: Marimuthu A]]
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[[Category: Milburn, M V.]]
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[[Category: Mehra U]]
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[[Category: Nguyen, H.]]
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[[Category: Milburn MV]]
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[[Category: Powell, B.]]
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[[Category: Nguyen H]]
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[[Category: Settachatgul, C.]]
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[[Category: Powell B]]
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[[Category: Shelloe, R.]]
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[[Category: Settachatgul C]]
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[[Category: Tabrizizad, M.]]
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[[Category: Shelloe R]]
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[[Category: Wang, W.]]
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[[Category: Tabrizizad M]]
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[[Category: West, B L.]]
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[[Category: Wang W]]
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[[Category: Zhang, C.]]
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[[Category: West BL]]
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[[Category: Liver receptor homologue-1]]
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[[Category: Zhang C]]
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[[Category: Lrh-1]]
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[[Category: Nuclear receptor]]
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[[Category: Phosphatidylethanolamine]]
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[[Category: Phospholipid]]
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[[Category: Transcription]]
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Current revision

The Crystal Structure of Human Liver Receptor Homologue-1

PDB ID 1zdu

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