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1zpi

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[[Image:1zpi.gif|left|200px]]
 
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==Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8224 complexed with CGCGAATTCGCG==
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The line below this paragraph, containing "STRUCTURE_1zpi", creates the "Structure Box" on the page.
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<StructureSection load='1zpi' size='340' side='right'caption='[[1zpi]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1zpi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZPI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SN9:8-METHOXY-1-METHYL-4-(4-(4-(1-METHYLPYRIDINIUM-4-YLAMINO)PHENYLCARBAMOYL)PHENYLAMINO)QUINOLINIUM'>SN9</scene></td></tr>
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{{STRUCTURE_1zpi| PDB=1zpi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zpi OCA], [https://pdbe.org/1zpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zpi RCSB], [https://www.ebi.ac.uk/pdbsum/1zpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zpi ProSAT]</span></td></tr>
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</table>
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'''Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8224 complexed with CGCGAATTCGCG'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Adams A]]
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The structures of the complexes formed between two anticancer minor-groove-binding quinolinium quaternary salts and the dodecamer d(CGCGAATTCGCG)(2) have been refined to resolutions of 1.6 and 1.8 Angstrom. The complexes crystallized in space group P2(1)2(1)2(1) and the structures are isomorphous with previously solved dodecamer structures. The ligands both bind in the central AT region of the minor groove and although the crystallization conditions and structures of the ligands are very similar, they bind in opposing orientations. The structures are compared with two previously published structures of quinolinium quaternary salts, refined at 2.5 Angstrom resolution, complexed with d(CGCGAATTCGCG)(2) and an e(6)G-modified DNA.
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[[Category: Denny WA]]
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[[Category: Guss JM]]
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==About this Structure==
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[[Category: Leong C]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPI OCA].
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==Reference==
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Structures of two minor-groove-binding quinolinium quaternary salts complexed with d(CGCGAATTCGCG)(2) at 1.6 and 1.8 Angstrom resolution., Adams A, Leong C, Denny WA, Guss JM, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1348-53. Epub 2005, Sep 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16204886 16204886]
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[[Category: Adams, A.]]
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[[Category: Denny, W A.]]
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[[Category: Guss, J M.]]
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[[Category: Leong, C.]]
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[[Category: B-dna]]
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[[Category: Dodecamer]]
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[[Category: Minor groove binding complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:55:01 2008''
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Current revision

Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8224 complexed with CGCGAATTCGCG

PDB ID 1zpi

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