2a5y

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{{Seed}}
 
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[[Image:2a5y.png|left|200px]]
 
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==Structure of a CED-4/CED-9 complex==
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The line below this paragraph, containing "STRUCTURE_2a5y", creates the "Structure Box" on the page.
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<StructureSection load='2a5y' size='340' side='right'caption='[[2a5y]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2a5y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. The September 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Apoptosomes'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_9 10.2210/rcsb_pdb/mom_2014_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A5Y FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2a5y| PDB=2a5y | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a5y OCA], [https://pdbe.org/2a5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a5y RCSB], [https://www.ebi.ac.uk/pdbsum/2a5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a5y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CED9_CAEEL CED9_CAEEL] Plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3.<ref>PMID:7907274</ref> <ref>PMID:9024666</ref> <ref>PMID:9027313</ref> <ref>PMID:9604928</ref> <ref>PMID:10688797</ref> <ref>PMID:15383288</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/2a5y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a5y ConSurf].
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<div style="clear:both"></div>
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===Structure of a CED-4/CED-9 complex===
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==See Also==
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*[[Cell death protein 3D structures|Cell death protein 3D structures]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16208361 is the PubMed ID number.
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</StructureSection>
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[[Category: Apoptosomes]]
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{{ABSTRACT_PUBMED_16208361}}
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==About this Structure==
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2A5Y is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5Y OCA].
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==Reference==
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Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans., Yan N, Chai J, Lee ES, Gu L, Liu Q, He J, Wu JW, Kokel D, Li H, Hao Q, Xue D, Shi Y, Nature. 2005 Oct 6;437(7060):831-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16208361 16208361]
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[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Gu, L.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Hao, Q.]]
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[[Category: Gu L]]
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[[Category: Liu, Q.]]
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[[Category: Hao Q]]
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[[Category: Shi, Y.]]
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[[Category: Liu Q]]
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[[Category: Yan, N.]]
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[[Category: Shi Y]]
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[[Category: Apoptosis]]
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[[Category: Yan N]]
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[[Category: Ced-3 activation]]
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[[Category: Ced-4]]
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[[Category: Ced-9]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:21:55 2008''
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Current revision

Structure of a CED-4/CED-9 complex

PDB ID 2a5y

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